{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:21Z","timestamp":1786978101666,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As the long\u2010term consequences of coronavirus disease 2019 (COVID\u201019) have not been defined, it is necessary to explore persistent symptoms, long\u2010term respiratory impairment, and impact on quality of life over time in COVID\u201019 survivors. In this prospective cohort study, convalescent individuals diagnosed with COVID\u201019 were followed\u2010up 2 and 3 years after discharge from hospital. Participants completed an in\u2010person interview to assess persistent symptoms and underwent blood tests, pulmonary function tests, chest high\u2010resolution computed tomography, and the 6\u2010min walking test. There were 762 patients at the 2\u2010year follow\u2010up and 613 patients at the 3\u2010year follow\u2010up. The mean age was 60 years and 415 (54.5%) were men. At 3 years, 39.80% of the participants had at least one symptom; most frequently, fatigue, difficulty sleeping, joint pain, shortness of breath, muscle aches, and cough. The participants experienced different degrees of pulmonary function impairment, with decreased carbon monoxide diffusion capacity being the main feature; results remained relatively stable over the 2\u20133 years. Multiple logistic regression analysis demonstrated that female sex and smoking were independently associated with impaired diffusion capacity. A subgroup analysis based on disease severity was performed, indicating that there was no difference in other parameters of lung function except forced vital capacity at 3\u2010year follow\u2010up. Persistent radiographic abnormalities, most commonly fibrotic\u2010like changes, were observed at both timepoints. At 3 years, patients had a significantly improved Mental Component Score compared with that at 2 years, with a lower percentage with anxiety. Our study indicated that symptoms and pulmonary abnormalities persisted in COVID\u201019 survivors at 3 years. Further studies are warranted to explore the long\u2010term effects of COVID\u201019 and develop appropriate rehabilitation strategies.<\/jats:p>","DOI":"10.1002\/jmv.29566","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T08:09:54Z","timestamp":1712218194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Two\u2010 and 3\u2010year outcomes in convalescent individuals with COVID\u201019: A prospective cohort study"],"prefix":"10.1002","volume":"96","author":[{"given":"Huqin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao\u2010Yang Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical 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