{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:58:24Z","timestamp":1753869504111,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) associated mucormycosis (CAM) was reported predominantly from India during the second wave of COVID\u201019 \u00a0and has a high mortality rate. The present study aims to understand the fungal community composition of the nasopharyngeal region of CAM\u2010infected individuals and compare it with severe COVID\u201019 patients and healthy controls. The fungal community composition was decoded by analyzing the sequence homology of the\u00a0internal transcribed spacer\u20102\u2013(ITS\u20102)\u00a0region of metagenomic DNA extracted from the upper respiratory samples. The alpha\u2010diversity indices were found to be significantly altered in CAM patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Interestingly, a higher abundance of <jats:italic>Candida africana<\/jats:italic>, <jats:italic>Candida haemuloni<\/jats:italic>, <jats:italic>Starmerella floris<\/jats:italic>, and <jats:italic>Starmerella lactiscondensi<\/jats:italic> was observed exclusively in CAM patients. The interindividual changes in mycobiome composition were well supported by beta\u2010diversity analysis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The current study provides insights into the dysbiosis of the nasal mycobiome during CAM infection. In conclusion, our study shows that severe COVID\u201019 and CAM are associated with alteration in mycobiome\u00a0as compared to healthy controls. However, the sequential alteration in the fungal flora which ultimately leads to the development of CAM needs to be addressed by future studies.<\/jats:p>","DOI":"10.1002\/jmv.29601","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T11:38:41Z","timestamp":1712749121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metagenomic insights into fungal community composition of the nasopharyngeal region of COVID\u201019 associated mucormycosis patients from India"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-7542","authenticated-orcid":false,"given":"Bharathi","family":"Arunan","sequence":"first","affiliation":[{"name":"Department of Medicine AIIMS New Delhi Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daizee","family":"Talukdar","sequence":"additional","affiliation":[{"name":"Functional Genomics Laboratory 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