{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:20:25Z","timestamp":1791854425926,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human adenovirus (HAdV) is a significant viral pathogen causing severe acute respiratory infections (SARIs) in children. To improve the understanding of type distribution and viral genetic characterization of HAdV in severe cases, this study enrolled 3404 pediatric SARI cases from eight provinces of China spanning 2017\u20132021, resulting in the acquisition of 112 HAdV strains. HAdV\u2010type identification, based on three target genes (penton base, hexon, and fiber), confirmed the diversity of HAdV types in SARI cases. Twelve types were identified, including species B (HAdV\u20103, 7, 55), species C (HAdV\u20101, 2, 6, 89, 108, P89H5F5, Px1\/Ps3H1F1, Px1\/Ps3H5F5), and E (HAdV\u20104). Among these, HAdV\u20103 exhibited the highest detection rate (44.6%), followed by HAdV\u20107 (19.6%), HAdV\u20101 (12.5%), and HAdV\u2010108 (9.8%). All HAdV\u20103, 7, 55, 4 in this study belonged to dominant lineages circulating worldwide, and the sequences of the three genes demonstrated significant conservation and stability. Concerning HAdV\u2010C, excluding the novel type Px1\/Ps3H1F1 found in this study, the other seven types were detected both in China and abroad, with HAdV\u20101 and HAdV\u2010108 considered the two main types of HAdV\u2010C prevalent in China. Two recombinant strains, including P89H5F5 and Px1\/Ps3H1F1, could cause SARI as a single pathogen, warranting close monitoring and investigation for potential public health implications. In conclusion, 5 years of SARI surveillance in China provided crucial insights into HAdV\u2010associated respiratory infections among hospitalized pediatric patients.<\/jats:p>","DOI":"10.1002\/jmv.29618","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T06:34:59Z","timestamp":1713508499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Genetic characterization of pediatric SARI\u2010associated human adenoviruses in eight Chinese provinces during 2017\u20132021"],"prefix":"10.1002","volume":"96","author":[{"given":"Jianlin","family":"Cai","sequence":"first","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 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