{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:33:31Z","timestamp":1790760811164,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Guangzhou has been the city most affected by the dengue virus (DENV) in China, with a predominance of DENV serotype 1 (DENV\u20101). Viral factors such as dengue serotype and genotype are associated with severe dengue (SD). However, none of the studies have investigated the relationship between DENV\u20101 genotypes and SD. To understand the association between DENV\u20101 genotypes and SD, the clinical manifestations of patients infected with different genotypes were investigated. A total of 122 patients with confirmed DENV\u20101 genotype infection were recruited for this study. The clinical manifestations, laboratory tests, and levels of inflammatory mediator factors were statistically analyzed to investigate the characteristics of clinical manifestations and immune response on the DENV\u20101 genotype. In the case of DENV\u20101 infection, the incidence of SD with genotype V infection was significantly higher than that with genotype I infection. Meanwhile, patients infected with genotype V were more common in ostealgia and bleeding significantly. In addition, levels of inflammatory mediator factors including IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u201010, and soluble vascular cell adhesion molecule 1 were higher in patients with SD infected with genotype V. Meanwhile, the concentrations of regulated upon activation normal T\u2010cell expressed and secreted and growth\u2010related gene alpha were lower in patients with SD infected with genotype V. The higher incidence of SD in patients infected with DENV\u20101 genotype V may be attributed to elevated cytokines and adhesion molecules, along with decreased chemokines.<\/jats:p>","DOI":"10.1002\/jmv.29635","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T06:25:04Z","timestamp":1714371904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genotype of dengue virus serotype 1 in relation to severe dengue in Guangzhou, China"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8702-3237","authenticated-orcid":false,"given":"Xing\u2010Yu","family":"Leng","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Guangzhou Medical Research Institute of Infectious Diseases,\u00a0Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Institution of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-1329","authenticated-orcid":false,"given":"Ling\u2010Zhai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Guangzhou Eighth People's Hospital, Guangzhou Medical Research Institute of Infectious Diseases Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Guangzhou Medical Research Institute of Infectious Diseases,\u00a0Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Institution of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang\u2010Hong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Guangzhou Medical Research Institute of Infectious Diseases,\u00a0Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Institution of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Min","family":"Feng","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Institution of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Chun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Guangzhou Medical Research Institute of Infectious Diseases,\u00a0Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Institution of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Dengue haemorrhagic fever: diagnosis, treatment, prevention, and control","author":"World Health Organization","year":"1997"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0521"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization.Ten threats to global health in 2019.https:\/\/www.who.int\/zh\/news-room\/spotlight\/ten-threats-to-global-health-in-2019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2023.100539"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01610-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00229-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00578-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12080829"},{"key":"e_1_2_9_10_1","unstructured":"World Health Organization. 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