{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:30:01Z","timestamp":1790371801038,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>While dysfunctional exhausted CD8+ T cells hamper viral control when children acquire hepatitis B virus (HBV) infection, it's crucial to recognize that CD8+ T cells have diverse phenotypes and functions. This study explored a subset of CD8+ T cells expressing C\u2010C chemokine receptor type 5 (CCR5) in children with HBV infection.\u00a0Thirty\u2010six patients in the immune tolerant\u00a0group, 33 patients in the immune active\u00a0group, 55 patients in the combined response\u00a0group, and 22 healthy control\u00a0children were enrolled. The frequency, functional molecules, and effector functions of the CCR5+CD8+ T cell population in different groups were evaluated.\u00a0The frequency of CCR5+CD8+ T cells correlated positively with the frequency of CCR5+CD4+ T cells and patient age, and it correlated negatively with alanine aminotransferase, aspartate transaminase, HBV DNA, hepatitis B surface antigen, and lactic dehydrogenase levels. CCR5+CD8+ T cells had higher levels of inhibitory and activated receptors and produced higher levels of IFN\u2010\u03b3, IL\u20102, and TNF\u2010\u03b1 than CCR5\u2010CD8+ T cells.\u00a0CCR5+CD8+ T cells were partially exhausted but possessed a stronger antiviral activity than CCR5\u2010CD8+ T cells. The identification of this subset increases our understanding of CD8+ T cell functions and serves as a potential immunotherapeutic target for children with HBV infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.29661","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T06:15:40Z","timestamp":1715580940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A potential antiviral role for CCR5+CD8+ T cells in children with hepatitis B"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6306-7757","authenticated-orcid":false,"given":"Aoxue","family":"Tan","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Child Infection and Immunity, Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Child Infection and Immunity, Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Child Infection and Immunity, Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing 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