{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:35:53Z","timestamp":1787952953707,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effectiveness of herpes zoster (HZ) vaccines in patients with diabetes over the age of 50 remains an active area of research. Utilizing a real\u2010world database from the US community, this study spanning from 2006 to 2023, aimed to evaluate the impact of HZ vaccination on newly diagnosed diabetes patients who received an HZ vaccination within 1 year of diagnosis. Exclusion criteria were established to omit patients with immune deficiencies. The cohort consisted of 53\u2009885 patients, with an average age of 63.5 years, including 43% females and 58% whites. After implementing 1:1 propensity score matching for age, sex, race, comorbidities, diabetes medication, and hemoglobin A1c to ensure comparability, the study population was further stratified into four groups: N1 comparing any HZ vaccination to non\u2010HZ vaccination (53\u2009882 matched pairs), N2 for Shingrix versus non\u2010HZ vaccination (16\u2009665 matched pairs), N3 for Zostavax versus non\u2010HZ vaccination (12\u2009058 matched pairs), and N4 for Shingrix versus Zostavax (11\u2009721 matched pairs). Cox proportional hazards regression analysis revealed a hazard ratio (HR) for HZ incidence post any HZ vaccination of 0.92 (95% confidence interval [CI]: 0.83\u20131.01). Additional analyses yielded HRs of 1.12 (95% CI: 0.93\u20131.34) for Shingrix versus non\u2010HZ vaccine, 1.02 (95% CI: 0.86\u20131.20) for Zostavax versus non\u2010HZ vaccine, and 1.06 (95% CI: 0.87\u20131.29) for Shingrix versus Zostavax. Subgroup analyses across age, sex, and follow\u2010up duration also showed no significant differences. These findings underscore the lack of a significant benefit from HZ vaccination in newly diagnosed diabetes patients aged over 50, highlighting the necessity for further prospective research.<\/jats:p>","DOI":"10.1002\/jmv.29667","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:48:39Z","timestamp":1715579319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessing herpes zoster vaccine efficacy in patients with diabetes: A community\u2010based cohort study"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9342-5467","authenticated-orcid":false,"given":"Edy","family":"Kornelius","sequence":"first","affiliation":[{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism Chung Shan Medical University Hospital  Taichung 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