{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:03:52Z","timestamp":1791299032747,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000888","name":"W. M. 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Although severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) virus mainly infects the respiratory system, neurological complications are widely reported in both acute infection and long\u2010COVID cases. Despite the success of vaccines and antiviral treatments, neuroinvasiveness of SARS\u2010CoV\u20102 remains an important question, which is also centered on the mystery of whether the virus is capable of breaching the barriers into the central nervous system. By studying the K18\u2010hACE2 infection model, we observed clear evidence of microvascular damage and breakdown of the blood\u2010brain barrier (BBB). Mechanistically, SARS\u2010CoV\u20102 infection caused pericyte damage, tight junction loss, endothelial activation and vascular inflammation, which together drive microvascular injury and BBB impairment. In addition, the blood\u2010cerebrospinal fluid barrier at the choroid plexus was also impaired after infection. Therefore, cerebrovascular and choroid plexus dysfunctions are important aspects of COVID\u201019 and may contribute to neurological complications both acutely and in long COVID.<\/jats:p>","DOI":"10.1002\/jmv.29671","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T03:57:43Z","timestamp":1715745463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["SARS\u2010CoV\u20102 induces blood\u2010brain barrier and choroid plexus barrier impairments and vascular inflammation in mice"],"prefix":"10.1002","volume":"96","author":[{"given":"Haowen","family":"Qiao","sequence":"first","affiliation":[{"name":"Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine University of Southern California Los Angeles California 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