{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:25Z","timestamp":1772118745954,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Early confirmation of sustained virologic response (SVR) or viral relapse after direct\u2010acting antivirals (DAAs) for hepatitis C virus (HCV) infection is essential based on public health perspectives, particularly for patients with high risk of nonadherence to posttreatment follow\u2010ups. A total of 1011 patients who achieved end\u2010of\u2010treatment virologic response, including 526 receiving fixed\u2010dose pangenotypic DAAs, and 485 receiving other types of DAAs, who had available off\u2010treatment weeks 4 and 12 serum HCV RNA data to confirm SVR at off\u2010treatment week 12 (SVR\n                    <jats:sub>12<\/jats:sub>\n                    ) or viral relapse were included. The positive predictive value (PPV) and negative predictive value (NPV) of SVR\n                    <jats:sub>4<\/jats:sub>\n                    to predict patients with SVR\n                    <jats:sub>12<\/jats:sub>\n                    or viral relapse were reported. Furthermore, we analyzed the proportion of concordance between SVR\n                    <jats:sub>12<\/jats:sub>\n                    and SVR\n                    <jats:sub>24<\/jats:sub>\n                    in 943 patients with available SVR\n                    <jats:sub>24<\/jats:sub>\n                    data. The PPV and NPV of SVR\n                    <jats:sub>4<\/jats:sub>\n                    to predict SVR\n                    <jats:sub>12<\/jats:sub>\n                    were 98.5% (95% confidence interval [CI]: 98.0\u201398.9) and 100% (95% CI: 66.4\u2013100) in the entire population. The PPV of SVR\n                    <jats:sub>4<\/jats:sub>\n                    to predict SVR\n                    <jats:sub>12<\/jats:sub>\n                    in patients receiving fixed\u2010dose pangenotypic DAAs was higher than those receiving other types of DAAs (99.8% [95% CI: 98.9\u2013100] vs. 97.1% [95% CI: 96.2\u201397.8],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The NPVs of SVR\n                    <jats:sub>4<\/jats:sub>\n                    to predict viral relapse were 100%, regardless of the type of DAAs. Moreover, the concordance between SVR\n                    <jats:sub>12<\/jats:sub>\n                    and SVR\n                    <jats:sub>24<\/jats:sub>\n                    was 100%. In conclusion, an off\u2010treatment week 4 serum HCV RNA testing is sufficient to provide an excellent prediction power of SVR or viral relapse at off\u2010treatment week 12 among patients with HCV who are treated with fixed\u2010dose pangenotypic DAAs.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29675","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T03:58:22Z","timestamp":1715745502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Four weeks of off\u2010treatment follow\u2010up is sufficient to determine virologic responses at off\u2010treatment week 12 in patients with hepatitis C virus infection receiving fixed\u2010dose pangenotypic direct\u2010acting antivirals"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-9707","authenticated-orcid":false,"given":"Chen\u2010Hua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital  Yun\u2010Lin Branch Yunlin Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ping","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Yuh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Yun\u2010Lin Branch Yunlin Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology Ditmanson Medical Foundation Chiayi Christian Hospital  Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Yu","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,\u00a0Division of Gastroenterology and Hepatology Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine, School of Medicine, Division of Gastroenterology and Hepatology, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"TMU Research Center for Digestive Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Taipei Cancer Center Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Taipei City Hospital  Ren\u2010Ai Branch Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Shun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Institute of Biomedical Sciences National Chung Hsing University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Lueng","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Tri\u2010Service General Hospital National Defense Medical Center  Taipei 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Chin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Bei\u2010Hu Branch Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung\u2010Hung","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai\u2010Chung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Medical Research National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine and Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Jer","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine and Hospital  Taipei 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