{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:49:50Z","timestamp":1792183790628,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study evaluated the epidemiological and clinical characteristics of human metapneumovirus (hMPV) infection among hospitalized patients with acute respiratory infections during 2015\u20132021 and assessed the impact of the coronavirus disease 2019 pandemic on hMPV infection. A single\u2010center, retrospective cohort study was performed, including pediatric and adult patients with laboratory\u2010confirmed hMPV. Of a total of 990 patients, 253 (25.6%), 105 (10.6%), 121 (12.2%), and 511 (51.6%) belonged to age groups 0\u20132, 3\u201317, 18\u201359, and \u226560 years, respectively. The highest percentage (23.0%) of patients were hospitalized during 2019 and the lowest (4.7%) during 2020. Patients\u2009&lt;\u200918 years experienced high rates of comorbidities (immunodeficiencies: 14.4% and malignancies: 29.9%). Here, 37\/39 (94.9%) of all bronchiolitis cases were diagnosed in patients\u2009&lt;\u20092 years, whereas more patients in older age groups were diagnosed with pneumonia. A greater proportion of hMPV patients diagnosed with viral coinfection (mostly respiratory syncytial virus and adenovirus) were &lt;18 years. The highest percentages of intensive care unit admissions were recorded among patients\u2009&lt;\u200918 years. Our findings demonstrate that hMPV is an important cause of morbidity in young children and a possibly underestimated cause of morbidity among older adults.<\/jats:p>","DOI":"10.1002\/jmv.29709","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T08:00:44Z","timestamp":1717401644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Epidemiological and clinical characteristics of hospitalized human metapneumovirus patients in Israel, 2015\u20132021: A retrospective cohort study"],"prefix":"10.1002","volume":"96","author":[{"given":"Menucha","family":"Jurkowicz","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Central Virology Laboratory, Ministry of Health Chaim Sheba Medical Center Ramat Gan Israel"},{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Centre Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hodaya","family":"Cohen","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Ministry of Health Chaim Sheba Medical Center Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ital","family":"Nemet","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Ministry of Health Chaim Sheba Medical Center Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Keller","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Ariel University Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Leibovitz","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Centre Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilad","family":"Sherman","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Centre Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Or","family":"Kriger","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Centre Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Barkai","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Centre Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Mandelboim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, School of 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