{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:26:57Z","timestamp":1792985217723,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    SARS\u2010CoV\u20102 infection has been associated with the increased incidence of acute macular neuroretinopathy (AMN), an infrequent ocular disorder. However, the precise mechanisms underpinning AMN in the context of SARS\u2010CoV\u20102 infection (AMN\u2010SARS\u2010CoV\u20102) remain elusive. In this case\u2013control study, 14 patients diagnosed with AMN\u2010SARS\u2010CoV\u20102 between 2022\/12 and 2023\/3 were enrolled and compared with 14 SARS\u2010CoV\u20102\u2010infected individuals without AMN, who served as controls (SARS\u2010CoV\u20102\u2010no AMN). Metabolomic profiling using ultrahigh\u2010performance liquid chromatography\u2010online electrospray mass spectrometry\u00a0revealed significant alterations in serum metabolites in AMN\u2010SARS\u2010CoV\u20102 patients. Coagulation abnormalities were observed in AMN\u2010SARS\u2010CoV\u20102 patients, and their relationship with metabolic disorders was studied. Finally, a predictive model for AMN\u2010SARS\u2010CoV\u20102 was established. Seventy\u2010six\u00a0upregulated and 42 downregulated metabolites were identified in AMN\u2010SARS\u2010CoV\u20102 cases. Notably, arginine metabolism within the urea cycle was significantly altered, evidenced by variations in ornithine, citrulline,\u00a0\n                    <jats:sc>l<\/jats:sc>\n                    \u2010proline, and ADAM levels, correlating with abnormal coagulation markers like platelet crit, fibrinogen degradation product, and fibrinogen. Additionally, increased arginase 1 (AGR1) activity within the urea cycle and reduced nitric oxide synthase\u00a0activity were observed in AMN\u2010SARS\u2010CoV\u20102. The integration of urea cycle metabolite levels with coagulation parameters yielded a robust discriminatory model for AMN\u2010SARS\u2010CoV\u20102, as evidenced by an area under the curve\u00a0of 0.96. The findings of the present study enhance our comprehension of the underlying metabolic mechanisms associated with AMN\u2010SARS\u2010CoV\u20102 and offer potential diagnostic markers for this uncommon ocular disorder within the context of SARS\u2010CoV\u20102 infection.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29714","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T06:35:22Z","timestamp":1717569322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the metabolic and coagulation disruptions in SARS\u2010CoV\u20102\u2010associated acute macular neuroretinopathy: A case\u2013control study"],"prefix":"10.1002","volume":"96","author":[{"given":"Xiaojing","family":"Xiong","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"Department of Ophthalmology The Second Affiliated Hospital of 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