{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:02:32Z","timestamp":1787061752871,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Severe fever with thrombocytopenia syndrome (SFTS) is associated with a high death rate and lacks a targeted therapy plan. The ratio of blood urea nitrogen to albumin, known as BAR, is a valuable method for assessing the outlook of various infectious diseases. The objective of this research was to evaluate the effectiveness of BAR in forecasting the outcome of individuals with SFTS. Four hundred and thirty\u2010seven patients with SFTS from two clinical centers were included in this study according to inclusion and exclusion criteria. Clinical characteristics and test parameters of SFTS patients were analyzed between survival and fatal groups. Least absolute shrinkage and selection operator (LASSO) regression and Cox regression suggested that BAR might serve as a standalone prognostic indicator for patients with SFTS in the initial phase (hazard ratio\u2009=\u200918.669, 95% confidence interval [CI]: 8.558\u201340.725,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). And BAR had a better predictive effectiveness in clinical outcomes in patients with SFTS with an AUC of 0.832 (95% CI: 0.788\u20130.876,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), a cutoff value of 0.19, a sensitivity of 0.812, and a specificity of 0.726 compared to C\u2010reactive protein, procalcitonin, and platelet to lymphocyte ratio via receiver operating characteristic curve. KM (Kaplan Meier) curves demonstrated that high level of BAR was associated with poor survival condition in patients with SFTS. Furthermore, the high level of BAR was associated with long hospital stays and test paraments of kidney, liver, and coagulation function in survival patients. So, BAR could be used as a promising early warning biomarker of adverse outcomes in patients with SFTS.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29731","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T05:53:48Z","timestamp":1718690028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Blood urea nitrogen to albumin ratio is a novel predictor of fatal outcome for patients with severe fever with thrombocytopenia syndrome"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7426-3426","authenticated-orcid":false,"given":"Ye","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital of Anhui Medical University Hefei Anhui Province People's Republic of 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Hospital of Anhui Medical University Hefei Anhui Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital of Anhui Medical University Hefei Anhui Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010Man","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery First Affiliated Hospital of Anhui Medical University Hefei Anhui Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Jie","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Infection Hospital Area of the First Affiliated Hospital of University of Science and Technology of China (Hefei Infectious Disease Hospital) Hefei Anhui Province People's Republic of 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