{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:41:17Z","timestamp":1782297677215,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Phylum <jats:italic>Cressdnaviricota<\/jats:italic> consists of a large number of circular Rep\u2010encoding single\u2010stranded (CRESS)\u2010DNA viruses. Recently, metagenomic analyzes revealed their ubiquitous distribution in a diverse range of eukaryotes. Data relating to CRESS\u2010DNA viruses in humans remains scarce. Our study investigated the presence and genetic diversity of CRESS\u2010DNA viruses in human vaginal secretions. Vaginal swabs were collected from 28 women between 29 and 43 years old attending a fertility clinic in New York City. An exploratory metagenomic analysis was performed and detection of CRESS\u2010DNA viruses was confirmed through analysis of near full\u2010length sequences of the viral isolates. A phylogenetic tree was based on the REP open reading frame sequences of the CRESS\u2010DNA virus genome. Eleven nearly complete CRESS\u2010DNA viral genomes were identified in 16 (57.1%) women. There were no associations between the presence of these viruses and any demographic or clinical parameters. Phylogenetic analysis indicated that one of the sequences belonged to the genus <jats:italic>Gemycircularvirus<\/jats:italic> within the <jats:italic>Genomoviridae<\/jats:italic> family, while ten sequences represented previously unclassified species of CRESS\u2010DNA viruses.<\/jats:p><jats:p>Novel species of CRESS\u2010DNA viruses are present in the vaginal tract of adult women. Although they be transient commensal agents, the potential clinical implications for their presence at this site cannot be dismissed.<\/jats:p>","DOI":"10.1002\/jmv.29750","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T11:09:47Z","timestamp":1719918587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of CRESS\u2010DNA viruses in human vaginal secretions: An exploratory metagenomic investigation"],"prefix":"10.1002","volume":"96","author":[{"given":"Endrya do Socorro Foro","family":"Ramos","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de diversidade Viral, Instituto de Ci\u00eancias Biol\u00f3gicas, Departamento de Virologia Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-1052","authenticated-orcid":false,"given":"Tania 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