{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:47:31Z","timestamp":1768488451559,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In intensive care units, COVID\u201019 viral pneumonia patients (VPP) present symptoms similar to those of other patients with Nonviral infection (NV\u2010ICU). To better manage VPP, it is therefore interesting to better understand the molecular pathophysiology of viral pneumonia and to search for biomarkers that may clarify the diagnosis. The secretome being a set of proteins secreted by cells in response to stimuli represents an opportunity to discover new biomarkers. The objective of this study is to identify the secretomic signatures of VPP with those of NV\u2010ICU. Plasma samples and clinical data from NV\u2010ICU (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009104), VPP (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200930) or healthy donors (HD, n\u2009=\u200920) were collected at Nantes Hospital (France) upon admission. Samples were enriched for the low\u2010abundant proteins and analyzed using nontarget mass spectrometry. Specifically deregulated proteins (DEP) in VPP versus NV\u2010ICU were selected. Combinations of 2 to 4 DEPs were established. The differences in secretome profiles of the VPP and NV\u2010ICU groups were highlighted. Forty\u2010one DEPs were specifically identified in VPP compared to NV\u2010ICU. We describe five of the best combinations of 3 proteins (complement component C9, Ficolin\u20103, Galectin\u20103\u2010binding protein, Fibrinogen alpha, gamma and beta chain, Proteoglycan 4, Coagulation factor IX and Cdc42 effector protein 4) that show a characteristic receptor function curve with an area under the curve of 95.0%. This study identifies five combinations of candidate biomarkers in VPP compared to NV\u2010ICU that may help distinguish the underlying causal molecular alterations.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29756","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:40:23Z","timestamp":1718858423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Value of a secretomic approach for distinguishing patients with COVID\u201019 viral pneumonia among patients with respiratory distress admitted to intensive care unit"],"prefix":"10.1002","volume":"96","author":[{"given":"Ang\u00e9lique","family":"Blangy\u2010Letheule","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Vergnaud","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Dupas","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Habert","sequence":"additional","affiliation":[{"name":"University of Paris\u2010Est Cr\u00e9teil (UPEC), Inserm U955, Equipe 21, UMR_S955, APHP, H\u00f4pital H. Mondor\u2010A. Chenevier, Centre d'Investigation Clinique Bioth\u00e9rapie Cr\u00e9teil France"},{"name":"AP\u2010HP, Hopital Henri Mondor Creteil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Montnach","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid","family":"Oulehri","sequence":"additional","affiliation":[{"name":"Service d'Anesth\u00e9sie\u2010R\u00e9animation et M\u00e9decine p\u00e9ri\u2010Op\u00e9ratoire, Nouvel H\u00f4pital Civil, H\u00f4pitaux Universitaires de Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorian","family":"Hassoun","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Denis","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules","family":"Lecomte","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Persello","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Roquilly","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology Nantes France"},{"name":"CHU Nantes, INSERM, Nantes Universit\u00e9, Anesth\u00e9sie R\u00e9animation Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Courty","sequence":"additional","affiliation":[{"name":"University of Paris\u2010Est Cr\u00e9teil (UPEC), Inserm U955, Equipe 21, UMR_S955, APHP, H\u00f4pital H. Mondor\u2010A. Chenevier, Centre d'Investigation Clinique Bioth\u00e9rapie Cr\u00e9teil France"},{"name":"AP\u2010HP, Hopital Henri Mondor Creteil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Seve","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, TIMC, PROMETHEE Proteomic Platform Saint\u2010Martin\u2010D'h\u00e8res France"},{"name":"CHU Grenoble Alpes, Institut de Biologie et de Pathologie, PROMETHEE Proteomic Platform Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lia A.","family":"Leroux","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"},{"name":"Oniris Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Rozec","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Bourgoin\u2010Voillard","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, TIMC, PROMETHEE Proteomic Platform Saint\u2010Martin\u2010D'h\u00e8res France"},{"name":"CHU Grenoble Alpes, Institut de Biologie et de Pathologie, PROMETHEE Proteomic Platform Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"De Waard","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"},{"name":"LabEx Ion Channels, Science and Therapeutics Valbonne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Lauzier","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"e_1_2_11_3_1","unstructured":"2022. 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