{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:33:34Z","timestamp":1791401614266,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>No effective treatments can ameliorate symptoms of long COVID patients. Our study assessed the safety and efficacy of human umbilical cord\u2010derived mesenchymal stem cells (UC\u2010MSCs) in the treatment of long COVID patients. Ten long COVID patients were enrolled and received intravenous infusions of UC\u2010MSCs on Days 0, 7, and 14. Adverse events and clinical symptoms were recorded, and chest\u2010high\u2010resolution CT (HRCT) images and laboratory parameters were analyzed. During UC\u2010MSCs treatment and follow\u2010up, we did not observe serious adverse events, the symptoms of long COVID patients were significantly relieved in a short time, especially sleep difficulty, depression or anxiety, memory issues, and so forth, and the lung lesions were also repaired. The routine laboratory parameters did not exhibit any significant abnormalities following UC\u2010MSCs transplantation (UMSCT). The proportion of regulatory T cells gradually increased, but it was not statistically significant until 12 months. The proportion of naive B cells was elevated, while memory B cells, class\u2010switched B\u2010cells, and nonswitched B\u2010cells decreased at 1 month after infusion. Additionally, we observed a transient elevation in circulating interleukin (IL)\u22126 after UMSCT, while tumor necrosis factor (TNF)\u2010\u03b1, IL\u201017A, and IL\u201010 showed no significant changes. The levels of circulating immunoglobulin (Ig) M increased significantly at month 2, while IgA increased significantly at month 6. Furthermore, the SARS\u2010CoV\u20102 IgG levels remained consistently high in all patients at Month 6, and there was no significant decrease during the subsequent 12\u2010month follow\u2010up. UMSCT was safe and tolerable in long COVID patients. It showed potential in alleviating long COVID symptoms and improving interstitial lung lesions.<\/jats:p>","DOI":"10.1002\/jmv.29757","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:34:47Z","timestamp":1718858087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Human umbilical cord\u2010derived mesenchymal stem cell transplantation improves the long COVID"],"prefix":"10.1002","volume":"96","author":[{"given":"Yuling","family":"Tang","sequence":"first","affiliation":[{"name":"The Affiliated Changsha Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Changsha Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Dai","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Su","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Tang","sequence":"additional","affiliation":[{"name":"The Affiliated Changsha Hospital of Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Mei","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"},{"name":"Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqi","family":"Ou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"},{"name":"Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science Central South University Changsha China"},{"name":"Hunan International Scientific and Technological Cooperation Base of Development and Carcinogenesis Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"},{"name":"Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science Central South University Changsha China"},{"name":"Hunan International Scientific and Technological Cooperation Base of Development and Carcinogenesis Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiu","family":"Lu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"},{"name":"Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science Central South University Changsha China"},{"name":"Hunan International Scientific and Technological Cooperation Base of Development and Carcinogenesis Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha China"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lin","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"},{"name":"Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science Central South University Changsha China"},{"name":"Hunan International Scientific and Technological Cooperation Base of Development and Carcinogenesis Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha China"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8685-3674","authenticated-orcid":false,"given":"Lamei","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Human Stem cell Changsha China"},{"name":"Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science Central South University Changsha China"},{"name":"Hunan International Scientific and Technological Cooperation Base of Development and Carcinogenesis Changsha China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Coronavirus Disease (COVID\u201019) Dashboard","author":"World Health Organization (WHO)"},{"key":"e_1_2_11_3_1","volume-title":"A Clinical Case Definition of Post COVID\u201019 Condition by a Delphi Consensus","author":"WHO"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03553-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00846-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2220578"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.18931"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02521-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2021.1924397"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30434-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100663"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"36","article-title":"Long COVID: complications, underlying mechanisms, and treatment strategies","volume":"7","author":"Zadeh FH","year":"2023","journal-title":"Arch Microbiol Immunol"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02001-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61167-z"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1068114"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201207-1204PP"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121731"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0711"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00286-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103789"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.23897"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01059-y"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7537589"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9803066"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01214-4"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01755-4"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32656-8"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00127-8"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03522-1"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.07.018"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201903809"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002944"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00174-0"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00488-5"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac722"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.850744"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0348"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2023.03.002"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01359-7"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01113-x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"crossref","unstructured":"KleinJ WoodJ JaycoxJ et al. Distinguishing features of Long COVID identified through immune profiling.Nature.2023;623:139\u2010148.https:\/\/doi.org\/10.1038\/s41586-023-06651-y","DOI":"10.1038\/s41586-023-06651-y"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244855"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.89"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113006"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0001"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12857"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00573-y"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268822000528"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0528"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:46:00Z","timestamp":1763707560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/jmv.29757"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29757","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29757"}}