{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:17:34Z","timestamp":1790371054639,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The most prevalent malignancy that complicates both adult and pediatric solid organ transplantation is post\u2010transplant lymphoproliferative disorder (PTLD). This study aimed to analyze the clinical and pathological characteristics, treatments, and outcomes of Epstein\u2010Barr virus (EBV) DNAemia and PTLD in pediatric liver transplant recipients. A retrospective chart review was performed on 112 patients less than 18 years of age who underwent isolated orthotopic liver transplantation (OLT) between 2010 and 2022 at Ege University Children's Hospital. Data gathered for 1\u2010year post\u2010OLT included age at OLT, EBV, immunoglobulin (Ig)M\/IgG status of the donor and recipient, indication for OLT, induction regimen, all immunosuppression levels, date and result of EBV polymerase chain reaction testing, rejection episodes documented by liver biopsy, and the development of PTLD. Forty\u2010nine patients (43.75%) developed EBV DNAemia (median interval from surgery: 2 months, min\u2013max: 2\u201336), of which 43 (87.8%) grafts came from living donors, and 6 (12.2%) came from deceased donors. Nine (18.4%) patients died during follow\u2010up, and eight (16.3%) developed PTLD. Of these 8 patients; five patients developed EBV\u2010related disease, one child developed hemophagocytic lymphohistiocytosis, one developed aplastic anemia, and one child developed B cell lymphoma. When PTLD patients and without\u2010PTLD patients were compared, pediatric intensive care unit hospitalization, abnormal bone marrow biopsy findings, lymphadenopathy, age at diagnosis of EBV DNAemia, EBV viral load, tacrolimus (FK 506) pre\u2010infection, were higher and tacrolimus 1\u2010month levels were lower in patients with PTLD (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In logistic regression analysis, we showed that the age at diagnosis of EBV DNAemia was significantly higher in children with PTLD (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.045; OR: 1.389; 95% CI: 1.007\u20131.914). PTLD is a rare but severe complication associated with EBV after OLT. This study demonstrated that PTLD is associated with older age, higher tacrolimus blood levels before EBV DNAemia, and higher peak EBV viral load at 1 month of EBV DNAemia.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29767","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T01:35:50Z","timestamp":1719452150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Post\u2010transplant lymphoproliferative disorder associated Epstein\u2010Barr virus DNAemia after liver transplantation in children: Experience from single center"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-4252","authenticated-orcid":false,"given":"Barut","family":"Dogan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Disease, Department of Pediatrics Medical School of Ege University \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-4092","authenticated-orcid":false,"given":"Yildirim Arslan","family":"Sema","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics Medical School of Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9577-5815","authenticated-orcid":false,"given":"Kunay","family":"Bora","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Disease, Department of Pediatrics Medical School of Ege University \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-7346","authenticated-orcid":false,"given":"Umman","family":"Veysel","sequence":"additional","affiliation":[{"name":"Department of General Surgery Medical School of Ege University \u0130zmir 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-8856","authenticated-orcid":false,"given":"Derya","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical School of Ege University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7844-972X","authenticated-orcid":false,"given":"Nazan","family":"Ozsan","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical School of Ege University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9454-4521","authenticated-orcid":false,"given":"Mine","family":"Hekimgil","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical School of Ege University \u0130zmir 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