{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:35:33Z","timestamp":1787243733089,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>COVID\u201019 tended to be less aggressive in dengue endemic regions. Conversely, dengue cases plummeted in dengue endemic zones during the active years of the pandemic (2020\u20132021). We and others have demonstrated serological cross\u2010reactivity between these two viruses of different families. We further demonstrated that COVID\u201019 serum samples that were cross\u2010reactive in dengue virus (DV) serological tests, \u201ccross\u2010neutralized\u201d all DV serotypes in Huh7 cells. Here we showed by co\u2010immunoprecipitation (Co\u2010IP) and atomic force microscopy (AFM) imaging that severe acute respiratory syndrome (SARS)\u2010coronavirus (CoV)\u20102 (SARS\u2010CoV\u20102) spike (S) protein subunit S1 and S2 monoclonal antibodies can indeed, bind to DV particles. Likewise, DV envelope antibodies (DV E Abs) showed high docking frequency with other human pathogenic beta\u2010CoVs and murine hepatitis virus\u20101 (MHV\u20101). SARS\u2010CoV\u20102 Ab didn't show docking or Co\u2010IP with MHV\u20101 supporting poor cross\u2010protection among CoVs. DV E Abs showed binding to MHV\u20101 (AFM, Co\u2010IP, and immunofluorescence) and prepandemic dengue patients'\u00a0serum samples even \u201ccross\u2010neutralized\u201d MHV\u20101 plaques in cell culture. Furthermore, dengue serum samples showed marked inhibition potential in a surrogate virus\u2010based competitive enzyme\u2010linked immunosorbent assay, used for determining neutralizing Abs against SARS\u2010CoV\u20102 S protein receptor\u2010binding domain in COVID\u201019 serum samples. We therefore, provide multiple evidence as to why CoVs are epidemiologically less prevalent in highly dengue endemic regions globally.<\/jats:p>","DOI":"10.1002\/jmv.29771","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T01:45:41Z","timestamp":1719452741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evidences support that dengue virus can impart broad\u2010spectrum immunity against betacoronaviruses in dengue endemic regions"],"prefix":"10.1002","volume":"96","author":[{"given":"Abinash","family":"Mallick","sequence":"first","affiliation":[{"name":"Infectious Diseases and Immunology Division CSIR\u2010Indian Institute of Chemical Biology  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumi","family":"Sukla","sequence":"additional","affiliation":[{"name":"CHINTA TCG\u2010Centres for Research and Education in Science and Technology  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"De","sequence":"additional","affiliation":[{"name":"Department of Dermatology Calcutta National Medical College and Hospital  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9001-7150","authenticated-orcid":false,"given":"Subhajit","family":"Biswas","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Immunology Division CSIR\u2010Indian Institute of Chemical Biology  Kolkata India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"1","article-title":"COVID\u201019 virus infection and transmission are observably less in highly dengue\u2010endemic countries: is pre\u2010exposure to dengue virus protective against COVID\u201019 severity and mortality? 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