{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:22:58Z","timestamp":1792333378473,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Optimization of individual immunosuppression, which reduces the risks of both graft loss and patients' death, is considered the best approach to improve long\u2010term outcomes of renal transplantation. Torque Teno Virus (TTV) DNAemia has emerged as a potential biomarker reflecting the depth of therapeutic immunosuppression during the initial year post\u2010transplantation. However, its efficacy in long\u2010term monitoring remains uncertain. In a cohort study involving 34 stable kidney transplant recipients and 124 healthy volunteers, we established lower and upper TTV DNAemia thresholds (3.75\u20135.1 log10\u2009cp\/mL) correlating with T\u2010cell activatability, antibody response against flu vaccine, and risk for subsequent serious infections or cancer over 50 months. Validation in an independent cohort of 92 recipients confirmed that maintaining TTV DNAemia within this range in &gt;50% of follow\u2010up time points was associated with reduced risks of complications due to inadequate immunosuppression, including de novo DSA, biopsy\u2010proven antibody\u2010mediated rejection, graft loss, infections, or cancer. Multivariate analysis highlighted \u201cin\u2010target\u201d TTV DNAemia as the sole independent variable significantly linked to decreased risk for long\u2010term complications due to inadequate immunosuppression (odds ratio [OR]: 0.27 [0.09\u20130.77]; <jats:italic>p<\/jats:italic>\u2009=\u20090.019). Our data suggest that the longitudinal monitoring of TTV DNAemia in kidney transplant recipients could help preventing the long\u2010term complications due to inadequate immunosuppression.<\/jats:p>","DOI":"10.1002\/jmv.29806","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T11:05:31Z","timestamp":1721041531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long\u2010term complications of inadequate immunosuppression"],"prefix":"10.1002","volume":"96","author":[{"given":"Luc","family":"Chauvelot","sequence":"first","affiliation":[{"name":"Department of Transplantation,\u00a0Nephrology and Clinical Immunology Hospices Civils de Lyon, Groupement Hospitalier Centre Lyon France"},{"name":"CIRI, Centre International de Recherche en Infectiologie, Universit\u00e9 de Lyon, INSERM U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS UMR5308,\u00a0ENS de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Barba","sequence":"additional","affiliation":[{"name":"Department of Transplantation,\u00a0Nephrology and Clinical Immunology Hospices Civils de Lyon, Groupement Hospitalier Centre Lyon France"},{"name":"Lyon\u2010Est Medical Faculty, Claude Bernard University (Lyon 1) Lyon France"},{"name":"Department of Internal Medicine Hospices Civils de Lyon, Groupement Hospitalier Centre Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Saison","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, Universit\u00e9 de Lyon, INSERM U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS UMR5308,\u00a0ENS de Lyon Lyon France"},{"name":"French National Blood Service (EFS), HLA Laboratory Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Siska","sequence":"additional","affiliation":[{"name":"BioM\u00e9rieux SA, 138, Rue Louis PASTEUR, Parc Technologique Delta Sud Verniolle France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-9921","authenticated-orcid":false,"given":"Dorian","family":"Kulifaj","sequence":"additional","affiliation":[{"name":"BioM\u00e9rieux SA, 138, Rue Louis PASTEUR, Parc Technologique Delta Sud Verniolle France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J. L.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Groningen, University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Transplantation,\u00a0Nephrology and Clinical Immunology Hospices Civils de Lyon, Groupement Hospitalier Centre Lyon France"},{"name":"CIRI, Centre International de Recherche en Infectiologie, Universit\u00e9 de Lyon, INSERM U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS UMR5308,\u00a0ENS de Lyon Lyon France"},{"name":"Lyon\u2010Est Medical Faculty, Claude Bernard University (Lyon 1) Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Rabeyrin","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospices Civils de Lyon, Groupement Hospitalier Est Bron 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Groupement Hospitalier Centre Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lina","sequence":"additional","affiliation":[{"name":"CIRI, Centre International de Recherche en Infectiologie, Universit\u00e9 de Lyon, INSERM U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS UMR5308,\u00a0ENS de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Morelon","sequence":"additional","affiliation":[{"name":"Department of Transplantation,\u00a0Nephrology and Clinical Immunology Hospices Civils de Lyon, Groupement Hospitalier Centre Lyon France"},{"name":"CIRI, Centre International de Recherche en Infectiologie, Universit\u00e9 de Lyon, INSERM U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS UMR5308,\u00a0ENS de Lyon Lyon France"},{"name":"Lyon\u2010Est Medical Faculty, Claude Bernard University (Lyon 1) Lyon 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