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The incidence of HBV infection among repeat blood donors was investigated with a detailed HBV infection phase, focusing on the influence of anti\u2010HBs level. This study followed 3\u2009435\u2009653 donors for HBV DNA conversion over 4 years and 9 months. Infection phase was determined based on marker changes over DNA conversion. This study identified 115 hepatitis B surface antigen (HBsAg) conversions, 72 DNA\u2010only conversions, and 15 DNA plus anti\u2010hepatitis B core (anti\u2010HBc) conversions among donors all negative for HBV DNA, HBsAg, and anti\u2010HBc. Total incidence was 2.38\/100\u2009000 person\u2010years (PY). None of these 202 new HBV infections arose in the group with anti\u2010HBs titer \u2265 10\u2009mIU\/mL. In total, 30 anti\u2010HBc\u2010negative OBIs were identified (incidence; 0.35\/100\u2009000 PY); 7 showed typical secondary anti\u2010HBs response, and 23 showed stable anti\u2010HBc and anti\u2010HBs levels at DNA conversion. The HBV infection\u2010protective ability of anti\u2010HBs \u2265 10\u2009mIU\/mL was reinforced. In addition to new infections, the blood donor population includes anti\u2010HBc\u2010positive\u2010 and negative OBI with immune reactions or abortive HBV infection.<\/jats:p>","DOI":"10.1002\/jmv.29823","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T02:30:01Z","timestamp":1721701801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incidences of new hepatitis B infection and anti\u2010hepatitis B core\u2010negative occult hepatitis B infection among Japanese blood donors in relation to anti\u2010hepatitis B surface antigen levels"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-6839","authenticated-orcid":false,"given":"Masahiro","family":"Satake","sequence":"first","affiliation":[{"name":"Blood Service Headquarters Japanese Red Cross Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-7197","authenticated-orcid":false,"given":"Masaya","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Viral Pathogenesis and Controls National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Mizokami","sequence":"additional","affiliation":[{"name":"Genome Medical Sciences Project National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5669-4051","authenticated-orcid":false,"given":"Junko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO Fact Sheet. 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