{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:32:12Z","timestamp":1782444732134,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010Spike IgG antibodies against SARS\u2010CoV\u20102, which are elicited by vaccination and infection, are correlates of protection against infection with pre\u2010Omicron variants. Whether this association can be generalized to infections with Omicron variants is unclear. We conducted a retrospective cohort study with 8457 blood donors in Tyrol, Austria, analyzing 15,340 anti\u2010Spike IgG antibody measurements from March 2021 to December 2022 assessed by Abbott SARS\u2010CoV\u20102 IgG II chemiluminescent microparticle immunoassay. Using a Bayesian joint model, we estimated antibody trajectories and adjusted hazard ratios for incident SARS\u2010CoV\u20102 infection ascertained by self\u2010report or seroconversion of anti\u2010Nucleocapsid antibodies. At the time of their earliest available anti\u2010Spike IgG antibody measurement (median November 23, 2021), participants had a median age of 46.0 years (IQR 32.8\u201355.2), with 45.3% being female, 41.3% having a prior SARS\u2010CoV\u20102 infection, and 75.5% having received at least one dose of a COVID\u201019 vaccine. Among 6159 participants with endpoint data, 3700 incident SARS\u2010CoV\u20102 infections with predominantly Omicron sublineages were recorded over a median of 8.8 months (IQR 5.7\u201312.4). The age\u2010 and sex\u2010adjusted hazard ratio for SARS\u2010CoV\u20102 associated with having twice the anti\u2010Spike IgG antibody titer was 0.875 (95% credible interval 0.868\u20130.881) overall, 0.842 (0.827\u20130.856) during 2021, and 0.884 (0.877\u20130.891) during 2022 (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The associations were similar in females and males (P<jats:sub>interaction<\/jats:sub>\u2009=\u20090.673) and across age (P<jats:sub>interaction<\/jats:sub>\u2009=\u20090.590). Higher anti\u2010Spike IgG antibody titers were associated with reduced risk of incident SARS\u2010CoV\u20102 infection across the entire observation period. While the magnitude of association was slightly weakened in the Omicron era, anti\u2010Spike IgG antibody continues to be a suitable correlate of protection against newer SARS\u2010CoV\u20102 variants.<\/jats:p>","DOI":"10.1002\/jmv.29839","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:11:09Z","timestamp":1722939069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti\u2010Spike IgG antibodies as correlates of protection against SARS\u2010CoV\u20102 infection in the pre\u2010Omicron and Omicron era"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-3262","authenticated-orcid":false,"given":"Lisa","family":"Seekircher","sequence":"first","affiliation":[{"name":"Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics Medical University of Innsbruck Innsbruck 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M.","family":"Afonso","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Erasmus Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Gaber","sequence":"additional","affiliation":[{"name":"Blood donor service Tyrol of the Austrian Red Cross Rum Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Schennach","sequence":"additional","affiliation":[{"name":"Central Institute for Blood Transfusion and Immunology University Hospital Innsbruck, Tirol Kliniken GmbH Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7860-7144","authenticated-orcid":false,"given":"Anita","family":"Siller","sequence":"additional","affiliation":[{"name":"Central Institute for Blood Transfusion and Immunology University Hospital 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