{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:15Z","timestamp":1753869435661,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fucosyltransferase 2 (FUT2) gene, which regulates the formation of Histoblood group antigens, could determine the human susceptibility to norovirus. This study aimed to investigate the correlation between FUT2 gene polymorphism and susceptibility to norovirus gastroenteritis in Han Chinese population. A total of 212 children patients with acute gastroenteritis were enrolled. The stool and serum samples were collected respectively. We used the qPCR method to detect the norovirus infection status from the stool samples, and we used serum samples to detect the FUT2 polymorphism. A case\u2010control study was conducted to investigate the three common SNPs polymorphisms (rs281377, rs1047781, and rs601338) of FUT2 gene with sanger sequencing method. The results indicated that the homozygous genotypes and mutant allele of rs1047781 (A385T) would downgrade the risk of norovirus gastroenteritis in Chinese Han population (AA vs. TT, odds ratio [OR]\u2009=\u20090.098, 95% confidence interval [CI]\u2009=\u20090.026\u22120.370, <jats:italic>p<\/jats:italic>\u2009=\u20090.001; AA\u2009+\u2009AT vs. TT, OR\u2009=\u20090.118. 95% CI\u2009=\u20090.033\u22120.424, <jats:italic>p<\/jats:italic>\u2009=\u20090.001; A vs. T, OR\u2009=\u20090.528, 95% CI\u2009=\u20090.351\u22120.974, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). There were no significant difference of rs281377 (C357T) and rs601338 (G428A) polymorphisms between norovirus positive and norovirus negative groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The haplotype T\u2010T\u2010G was less susceptible (OR\u2009=\u20090.49, 95% CI\u2009=\u20090.31\u22120.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.0034) to norovirus infection compared to other haplotypes. Our results investigated the relationship between the FUT2 gene polymorphisms and norovirus susceptibility in Han Chinese population, and firstly revealed that children with homozygous genotypes and mutant alleles of FUT2 rs1047781 (A385T) were less susceptible to norovirus gastroenteritis.<\/jats:p>","DOI":"10.1002\/jmv.29848","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:10:38Z","timestamp":1722939038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of fucosyltransferase 2 gene polymorphism with the susceptibility to norovirus infection in Han Chinese population"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2284-0564","authenticated-orcid":false,"given":"Shun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Jingzhou Hospital Affiliated to Yangtze University  Jingzhou Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Jingzhou Hospital Affiliated to Yangtze University  Jingzhou Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Jingzhou Hospital Affiliated to Yangtze University  Jingzhou Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-2902","authenticated-orcid":false,"given":"Yaoling","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Jingzhou Hospital Affiliated to Yangtze University  Jingzhou Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9332-3356","authenticated-orcid":false,"given":"Bing","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Jingzhou Hospital Affiliated to Yangtze University  Jingzhou Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengbin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Jingzhou Hospital Affiliated to Yangtze University  Jingzhou Hubei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.105259"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30276-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151219"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01535-14"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.014855"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.64.95"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10020096"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1757"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10996"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12016"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0638"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.03.031"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33661"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12101084"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2020.04.017"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.24.15351-15355.2005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14766"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000443"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12663"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106408108"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"1","article-title":"FUT2 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