{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:30:44Z","timestamp":1770467444828,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to establish a novel noninvasive model based on the serum N\u2010glycan spectrum for providing an objective value for determining the stage of liver necroinflammation related to chronic hepatitis B (CHB) patients. N\u2010glycan profiles of the sera of 295 treatment\u2010na\u00efve CHB patients were analyzed. N\u2010glycan profiles were tested for different liver necroinflammation stages using DNA sequence\u2010assisted fluorophore\u2010assisted carbohydrate electrophoresis. A serum N\u2010glycan model named N\u2010glycan\u2010LI\u00a0(NGLI) using support vector machine was selected to evaluate the classification of liver necroinflammation (G\u2009&lt;\u20092 and G\u2009\u2265\u20092). The area under the receiver operating characteristic curves (AUROCs) was 0.898 (training set, <jats:italic>n<\/jats:italic>\u2009=\u2009236) and 0.911 (validation set, <jats:italic>n<\/jats:italic>\u2009=\u200959) regardless of the stage of liver fibrosis (AUROC\u2009=\u20090.886 and 0.926, respectively, in S\u2009&lt;\u20092 and S\u2009\u2265\u20092 group). The NGLI correspondingly had the highest specificity (SP) of 90.79% and negative predictive value of 92.00% in an inactive stage (including immune\u2010tolerant [IT] and inactive\u2010carrier [IC] stage), had the highest positive predictive value of 95.18% in stage immune\u2010active, and had the highest SP\u00a0of 93.94% in grey zone IT\u2009+\u2009IC. N\u2010glycan profiles appear to correlate well with hepatic necroinflammation in CHB when compared with liver biopsy. The newly developed model appears to reliably predict liver damage in na\u00efve\u2010treatment patients with CHB.<\/jats:p>","DOI":"10.1002\/jmv.29863","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:50:45Z","timestamp":1724295045000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A novel model based on serum N\u2010glycan markers for evaluating stage of liver necroinflammation in treatment\u2010na\u00efve chronic hepatitis B patients"],"prefix":"10.1002","volume":"96","author":[{"given":"Rui","family":"Su","sequence":"first","affiliation":[{"name":"School of Precision Instruments and Opto\u2010Electronics Engineering Tianjin University  Tianjin China"},{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Yan","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"},{"name":"Department of Microbiology &amp; Infectious Disease Center, School of Basic Medical Sciences Peking University Health Science Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggang","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Miao","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Research and Development Sysdiagno (Nanjing) Biotech Co. Ltd  Nanjing Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ren","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7809-2679","authenticated-orcid":false,"given":"Yuqiang","family":"Mi","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Heptology Tianjin Second People's Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-19"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29569"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23785"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i25.7869"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1083912"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105315"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15881"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.036"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0129-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-015-9626-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2014.11.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800470-MCP200"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21855"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/11.4.275"},{"issue":"1","key":"e_1_2_9_20_1","first-page":"41","article-title":"Applications of support vector machine (SVM) learning in cancer genomics","volume":"15","author":"Huang S","year":"2018","journal-title":"Cancer Genomics Proteomics"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i10.1067"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-380888-2.00002-9"},{"issue":"5","key":"e_1_2_9_23_1","first-page":"314","article-title":"Hepatitis B: screening, prevention, diagnosis, and treatment","volume":"99","author":"Wilkins T","year":"2019","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1119124"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.022"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12590"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.075"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1403"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.057"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1894"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.08.060"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6283"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3982"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0299403"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061404"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-22-93"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.12.025"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262291"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102419"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i21.2910"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2020.2969915"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2023.03.008"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022794"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40920"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800737u"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T13:07:24Z","timestamp":1727356044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/jmv.29863"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29863","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29863"}}