{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:29:48Z","timestamp":1770272988488,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060001"],"award-info":[{"award-number":["82060001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antigen presentation by HLA class II molecules to CD4<jats:sup>+<\/jats:sup> T cells is an essential step for generating antibodies to hepatitis B antigens. In this study, we investigated the association between the HLA\u2010DRB1 gene and the status of antibodies to hepatitis B surface and e antigens. Our results revealed a significant association between the status of anti\u2010HBsAg and HLA\u2010DRB1*04:03 (OR\u2009=\u20094.11, 95% CI\u2009=\u20091.50\u201310.84, <jats:italic>p<\/jats:italic>\u2009=\u20090.005, <jats:italic>P<\/jats:italic><jats:sub>adj.<\/jats:sub>\u2009=\u20090.05) as well as HLA\u2010DRB1*15:01 (OR\u2009=\u20091.74, 95% CI\u2009=\u20091.20\u20132.50, <jats:italic>p<\/jats:italic>\u2009=\u20090.002, <jats:italic>P<\/jats:italic><jats:sub>adj.<\/jats:sub>\u2009=\u20090.045). MHC II binding predictions and in silico docking demonstrated strong binding affinity of HBsAg peptides to these two HLA\u2010DRB1 molecules. Conversely, the status of anti\u2010HBeAg was inversely associated with HLA\u2010DRB1*14:54 (OR\u2009=\u20090.34, 95% CI\u2009=\u20090.18\u20130.64, <jats:italic>p<\/jats:italic>\u2009=\u20090.001, <jats:italic>P<\/jats:italic><jats:sub>adj.<\/jats:sub>\u2009=\u20090.011), and in silico analysis revealed weak binding affinity of HBeAg peptides to HLA\u2010DRB1*14:54. In conclusion, these findings support the involvement of HLA\u2010DRB1 in humoral immunity against HBV infection.<\/jats:p>","DOI":"10.1002\/jmv.29867","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T06:44:45Z","timestamp":1724309085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of HLA\u2010DRB1 alleles with status of antibodies to hepatitis B surface and e antigen"],"prefix":"10.1002","volume":"96","author":[{"given":"Xinze","family":"Li","sequence":"first","affiliation":[{"name":"Hainan Women and Children's Medical Center Haikou Hainan China"},{"name":"NHC Key Laboratory of Tropical Disease Control\uff0cSchool of Tropical Medicine Hainan Medical University Haikou Hainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaomiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hainan Women and Children's Medical Center Haikou Hainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Lu","sequence":"additional","affiliation":[{"name":"Hainan Women and Children's Medical Center Haikou Hainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renliang","family":"Huang","sequence":"additional","affiliation":[{"name":"Hainan Women and Children's Medical Center Haikou Hainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Lin","sequence":"additional","affiliation":[{"name":"Hainan Women and Children's Medical Center Haikou Hainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Hainan Women and Children's Medical Center Haikou Hainan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Hainan Women and Children's Medical Center Haikou 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