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In the current guideline, criteria for second\u2010generation comparator tests are presented that include more detailed resolution of HPV genotypes. Second\u2010generation comparator tests should preferentially target only the 12 genotypes classified as carcinogenic (IARC\u2010group I), and show consistent non\u2010inferior sensitivity for CIN2+ and CIN3+ and specificity for \u2264CIN1 compared to one of the first\u2010generations comparators, in at least three validation studies using benchmarks of 0.95 for relative sensitivity and 0.98 for relative specificity. Validation should take into account used storage media and other sample handling procedures. Meta\u2010analyses were conducted to identify the assays that fulfill these stringent criteria. Four tests fulfilled the new criteria: (1) RealTime High\u2010Risk HPV Test (Abbott), (2) Cobas\u20104800 HPV test (Roche Molecular System), (3) Onclarity HPV Assay (BD Diagnostics), and (4) Anyplex II HPV HR Detection (Seegene), each evaluated in three to six studies. Whereas the four assays target 14 carcinogenic genotypes, the first two identify separately HPV16 and 18, the third assay identifies five types separately and the fourth identifies all the types separately.<\/jats:p>","DOI":"10.1002\/jmv.29881","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T05:15:37Z","timestamp":1725254137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Criteria for second generation comparator tests in validation of novel HPV DNA tests for use in cervical cancer screening"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-5908","authenticated-orcid":false,"given":"Marc","family":"Arbyn","sequence":"first","affiliation":[{"name":"Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano Brussels 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