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Despite observations recently made in the relevant molecular, cellular, and physiological domains, it is still difficult to say whether the post\u2010acute sequelae of COVID\u201019 directly correspond to the consequences of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. This work hypothesizes that neutrophils and neutrophil extracellular traps (NETs) production are at the interconnection of three positive feedback loops which are initiated in the acute phase of SARS\u2010CoV\u20102 infection, and which involve inflammation, immunothrombosis, and autoimmunity. This phenomenon could be favored by the fact that SARS\u2010CoV\u20102 may directly bind and penetrate neutrophils. The ensuing strong neutrophil stimulation leads to a progressive amplification of an exacerbated and uncontrolled NETs production, potentially persisting for months beyond the acute phase of infection. This continuous self\u2010stimulation of neutrophils leads, in turn, to systemic inflammation, micro\u2010thromboses, and the production of autoantibodies, whose significant consequences include the persistence of endothelial and multiorgan damage, and vascular complications.<\/jats:p>","DOI":"10.1002\/jmv.29887","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T08:09:12Z","timestamp":1724746152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Inflammation\u2010, immunothrombosis,\u2010 and autoimmune\u2010feedback loops may lead to persistent neutrophil self\u2010stimulation in long COVID"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-5404","authenticated-orcid":false,"given":"Alain R.","family":"Thierry","sequence":"first","affiliation":[{"name":"IRCM Institute of Research on Cancerology of Montpellier, INSERM U1194, University 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