{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:10:07Z","timestamp":1792638607796,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The SARS\u2010CoV\u20102 Omicron variant is characterized by its high transmissibility, which has caused a worldwide epidemiological event. Yet, it turns ominous once the disease progression degenerates into severe pneumonia and sepsis, presenting a horrendous lethality. To elucidate the alveolar immune or inflammatory landscapes of Omicron critical\u2010ill patients, we performed single\u2010cell RNA\u2010sequencing (scRNA\u2010seq) of bronchoalveolar lavage fluid (BALF) from the patients with critical pneumonia caused by Omicron infection, and analyzed the correlation between the clinical severity scores and different immune cell subpopulations. In the BALF of Omicron critical patients, the alveolar violent myeloid inflammatory environment was determined. ISG15\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils and CXCL10\n                    <jats:sup>+<\/jats:sup>\n                    macrophages, both expressed the interferon\u2010stimulated genes (ISGs), were negatively correlated with clinical pulmonary infection score, while septic CST7\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils and inflammatory VCAN\n                    <jats:sup>+<\/jats:sup>\n                    macrophages were positively correlated with sequential organ failure assessment. The percentages of ISG15\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils were associated with more protective alveolar epithelial cells, and may reshape CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells to the exhaustive phenotype, thus preventing immune injuries. The CXCL10\n                    <jats:sup>+<\/jats:sup>\n                    macrophages may promote plasmablast\/plasma cell survival and activation as well as the production of specific antibodies. As compared to the previous BALF scRNA\u2010seq data from SARS\u2010CoV\u20102 wild\u2010type\/Alpha critical patients, the subsets of neutrophils and macrophages with pro\u2010inflammatory and immunoregulatory features presented obvious distinctions, suggesting an immune disparity in Omicron variants. Overall, this study provides a BALF single\u2010cell atlas of Omicron critical patients, and suggests that alveolar interferon\u2010responsive neutrophils and macrophages may extricate SARS\u2010CoV\u20102 Omicron critical patients from the nasty fate of sepsis.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29889","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T07:24:36Z","timestamp":1724916276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interferon\u2010responsive neutrophils and macrophages extricate SARS\u2010CoV\u20102 Omicron critical patients from the nasty fate of sepsis"],"prefix":"10.1002","volume":"96","author":[{"given":"Mu","family":"Wang","sequence":"first","affiliation":[{"name":"National Key Laboratory of Immunity and Inflammation, Institute of Immunology Second Military Medical University Shanghai 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