{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:38:45Z","timestamp":1784914725556,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The active form of vitamin D (VD) exerts hormonal effects by regulating the expression of genes involved in T\u2010cell activity, cell differentiation, and proliferation. Human T\u2010cell leukemia virus type 1 (HTLV\u20101) is a causative agent of life\u2010threatening diseases, adult T\u2010cell leukemia (ATL) and HTLV\u20101\u2010associated myelopathy (HAM). Among ATL patients, hypercalcemia is one of the most serious complications due to bone resorption. In this study, wild\u2010type mice administered UV\u2010irradiated HTLV\u20101\u2010infected cells showed up to 47% decrease of plasma VD level compared with untreated mice. To clarify the effect of HTLV\u20101 on plasma VD level, 315 samples registered in nationwide cohort study on ATL onset were measured. The VD level in HAM (14.98\u2009\u00b1\u20098.5\u2009ng\/mL) was significantly lower than those in asymptomatic carriers and ATL (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Upon comparing the VD levels in ATL stratified by disease subtypes, acute ATL showed a lower level (15.81\u2009\u00b1\u200912.0\u2009ng\/mL) than chronic and smoldering types (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In the longitudinal observation, VD levels were significantly higher in untreated spontaneous remission cases than in ATL progression cases, in which the VD levels decreased approximately 40% after onset. In cases of relapse after transplantation, the plasma VD level dropped to 38.7% of the pre\u2010relapse level, while in cases of complete remission, the VD level increased with improvement of the performance status. Taken together, these results suggest that plasma VD level is a potential indicator for the onset and relapse of HTLV\u20101\u2010associated diseases.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29898","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T05:28:05Z","timestamp":1725254885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma vitamin D levels are correlated with the pathogenesis of human T\u2010cell leukemia virus type 1\u2010associated diseases"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6322-7195","authenticated-orcid":false,"given":"Yasuko","family":"Sagara","sequence":"first","affiliation":[{"name":"Japanese Red Cross Kyushu Block Blood Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5225-7295","authenticated-orcid":false,"given":"Hitomi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kyushu Block Blood Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Sagara","sequence":"additional","affiliation":[{"name":"Faculty of Education Nakamura\u2010Gakuen University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Shitsuta","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kyushu Block Blood Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Uchimaru","sequence":"additional","affiliation":[{"name":"Laboratory of Tumor Cell Biology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Yamano","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Marianna University School of Medicine Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-3773","authenticated-orcid":false,"given":"Toshiki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Oncology St. Marianna University School of Medicine Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonori","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kyushu Block Blood Center Fukuoka 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