{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:38:06Z","timestamp":1789087086416,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Severe fever with thrombocytopenia syndrome (SFTS) represents an emerging infectious disease characterized by a substantial mortality risk. Early identification of patients is crucial for effective risk assessment and timely interventions. In the present study, least absolute shrinkage and selection operator (LASSO)\u2010Cox regression analysis was conducted to identify key risk factors associated with progression to critical illness at 7\u2010day and 14\u2010day. A nomogram was constructed and subsequently assessed for its predictive accuracy through evaluation and validation processes. The risk stratification of patients was performed using X\u2010tile software. The performance of this risk stratification system was assessed using the Kaplan\u2013Meier method. Additionally, a heat map was generated to visualize the results of these analyses. A total of 262 SFTS patients were included in this study, and four predictive factors were included in the nomogram, namely viral copies, aspartate aminotransferase (AST) level, C\u2010reactive protein (CRP), and neurological symptoms. The AUCs for 7\u2010day and 14\u2010day were 0.802 [95% confidence interval (CI): 0.707\u20130.897] and 0.859 (95% CI: 0.794\u20130.925), respectively. The nomogram demonstrated good discrimination among low, moderate, and high\u2010risk groups. The heat map effectively illustrated the relationships between risk groups and predictive factors, providing valuable insights with high predictive and practical significance.<\/jats:p>","DOI":"10.1002\/jmv.29921","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T02:14:32Z","timestamp":1726798472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A nomogram and heat map based on LASSO\u2010Cox regression for predicting the risk of early\u2010stage severe fever with thrombocytopenia syndrome patients developing into critical illness at 7\u2010day and 14\u2010day"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-2069","authenticated-orcid":false,"given":"Hanwen","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naisheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1942-8806","authenticated-orcid":false,"given":"Haopeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binxia","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Oncology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, School of Pharmacy Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit603"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203378"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3092-y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0214-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005893"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010095"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30293-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis472"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2014.12.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.01.006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2008.131796"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70222-X"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0713"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.03.017"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir804"},{"issue":"2","key":"e_1_2_11_19_1","first-page":"203","article-title":"Elements of graphing data. by william s. Cleveland","volume":"25","author":"Harris FS","year":"1986","journal-title":"Appl Opt"},{"issue":"2","key":"e_1_2_11_20_1","first-page":"167","article-title":"Impact of c\u2010reactive protein on disease risk and its relation to dietary factors","volume":"8","author":"Nanri A","year":"2007","journal-title":"Asian Pacific journal of cancer prevention: APJCP"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06921-6"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.05.013"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3773-1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.725642"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2021.00345"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1686-y"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26877"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0485-6"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2019-136409"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07320-7"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6645"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.821-835.2001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1118039"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00612-12"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3036"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007829"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0412-3"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:40:51Z","timestamp":1763224851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/jmv.29921"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29921","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29921"}}