{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:57Z","timestamp":1786978197316,"version":"build-2736575974"},"reference-count":6,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n We performed a\u00a0comparative, retrospective analysis (March 2019\u2013April 2023) of children diagnosed with non\u2010polio enterovirus (NPEV) central nervous system (CNS) infections (\n n<\/jats:italic>\n \u2009=\u200947 vs. 129 contemporaneous controls without NPEV, all <18 years old), requiring cerebrospinal fluid (CSF) testing upon presentation to hospital. We found that showed that admissions decreased during pandemic restrictions (13% vs. controls 33%,\n p<\/jats:italic>\n \u2009=\u20090.003). The median age of children with NPEV was 41 days (IQR: 18\u201372), most were male (\n n<\/jats:italic>\n \u2009=\u200976, 59%) and were less likely to present with symptoms of irritability (11% vs. controls 26%,\n p<\/jats:italic>\n \u2009=\u20090.04), but more likely to be febrile (93% vs. controls 73%,\n p<\/jats:italic>\n \u2009=\u20090.007), have higher respiratory rates (mean 44 bpm, SD 11, vs. controls 36 bpm, SD 14,\n p<\/jats:italic>\n \u2009=\u20090.001), higher heart rates (mean 171 bpm, SD 27 vs. controls 141 bpm, SD 36,\n p<\/jats:italic>\n \u2009<\u20090.001), higher CSF protein (median 0.66\u2009g\/L, interquartile range [IQR] 0.46\u20131.01, vs. controls 0.53\u2009mg\/mL, IQR 0.28\u20130.89,\n p<\/jats:italic>\n \u2009=\u20090.04), higher CSF white cell count (WCC) (median WCC 9.5\u00d710\n 6<\/jats:sup>\n \/L, IQR 1\u201316 vs. controls 3.15\u00d710\n 6<\/jats:sup>\n \/L, IQR 2.7\u20133.6,\n p<\/jats:italic>\n \u2009<\u20090.001), but lower CSF glucose (median 2.8\u2009mmol\/L, IQR 2.4\u20133.1 vs. controls 3.1\u2009mmol\/L, IQR 2.7\u20133.6,\n p<\/jats:italic>\n \u2009<\u20090.001). Phylogenetic analysis showed that these NPEVs originated from Europe (EV A71, CV B4, E21, E6, CV B3, CV B5, E7, E11, E18), North America (CV B4, E18), South America (E6), Middle East (CV B5), Africa (CV B5, E18), South Asia (E15), East\/Southeast Asia (E25, CV A9, E7, E11, E18), and Australia (CV B5).\n <\/jats:p>","DOI":"10.1002\/jmv.29924","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T02:45:21Z","timestamp":1726713921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and molecular epidemiology of enterovirus infections in cerebrospinal fluid samples, 2019\u20132023"],"prefix":"10.1002","volume":"96","author":[{"given":"Daniel","family":"Pan","sequence":"first","affiliation":[{"name":"Development Centre for Population Health University of Leicester Leicester UK"},{"name":"Department of Respiratory Sciences University of Leicester Leicester UK"},{"name":"Department of Infectious Diseases and HIV Medicine University Hospitals of Leicester NHS Trust Leicester UK"},{"name":"Leicester NIHR Biomedical Research Centre Leicester UK"},{"name":"Li Ka Shing Centre for Health Information and Discovery University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basant","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaki","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and HIV Medicine University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Strachan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and HIV Medicine University Hospitals of Leicester NHS Trust Leicester UK"},{"name":"Department of Clinical Microbiology University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Celma","sequence":"additional","affiliation":[{"name":"UK Enteric Virus Unit, Virus Reference Department UK Health Security Agency, Colindale Colindale UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver T. R.","family":"Toovey","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Beard","sequence":"additional","affiliation":[{"name":"UK Enteric Virus Unit, Virus Reference Department UK Health Security Agency, Colindale Colindale UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4963-1028","authenticated-orcid":false,"given":"Julian W.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Sciences University of Leicester Leicester UK"},{"name":"Department of Clinical Microbiology University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.39.2300313"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30566-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2701.203394"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.06.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13030434"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104516"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:41:13Z","timestamp":1763224873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":6,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/jmv.29924"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29924","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29924"}}