{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:04:04Z","timestamp":1777943044187,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Studies have pointed to a decisive role of autoantibodies in the context of sepsis and severe Coronavirus disease 2019 (COVID\u201019), which itself often fulfills the criteria for sepsis, including dysregulated immune responses and organ dysfunction. To directly compare and further analyze the autoantibody profiles of sepsis patients with and without COVID\u201019, the luciferase immunoprecipitation systems (LIPS) assay was used to measure the levels of autoantibodies against a variety of clinically relevant cytokines, lung\u2010associated proteins, other autoantigens, and antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). In addition, cytokine titers were measured with the LEGENDplex\u2122 Human Antivirus Response Panel. We observed significantly increased levels of autoantibodies in 59% of the COVID\u201019\u2010Sepsis group compared to 48% of the Sepsis group. Significant differences were identified between the groups for the levels of autoantibodies against gATPase. The cytokine levels of interferon (IFN)\u2010\u03bb1 and IP\u201010 were higher in the COVID\u201019\u2010Sepsis group\u00a0compared to the Sepsis group. Additional correlations between autoantibodies, cytokines and 30\u2010day survival could be demonstrated, suggesting varied underlying pathological mechanisms. Elevated levels of cytokines and autoantibodies may serve as prognostic indicators for the survival probability of sepsis patients, highlighting the intricate relationship between immune responses and patient outcomes in the context of both sepsis and COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.29935","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T01:24:17Z","timestamp":1727313857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Divergent autoantibody and cytokine levels in COVID\u201019 sepsis patients influence survival"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-9877","authenticated-orcid":false,"given":"Daniel","family":"K\u00fchn","sequence":"first","affiliation":[{"name":"Department for Molecular and Medical Virology Ruhr University Bochum Bochum 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