{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:02:27Z","timestamp":1789714947618,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The presence of pretreatment drug resistance (PDR) is posing an increasing threat to HIV control. Here we investigated drug resistance mutations (DRMs) and PDR among 6831 HIV\u2010infected individuals from 2018 to 2022 in Guangzhou, China. DRMs were detected among 24.5% of the patients. The overall prevalence of PDR was 7.4%, with resistance rate to nucleotide reverse transcriptase inhibitor (NRTI) being 1.3%, nonnucleoside reverse transcriptase inhibitor (NNRTI) 4.8%, and protease inhibitor (PI) 1.4%. Abacavir (0.8%) resistance was the most common in NRTI, followed by resistance to emtricitabine (0.6%), lamivudine (0.6%), and tenofovir disoproxil fumarate (0.3%). In NNRTI, nevirapine (3.7%) resistance was the most common, followed by efavirenz (3.5%) and rilpivirine (3.4%). Among PI, resistance to tipranavir (0.8%), nelfinavir (0.6%), fosamprenavir (0.2%) and lopinavir (0.1%) was most frequent. Annual prevalence of PDR showed an increase trend from 2018 to 2022, although not significant. In the multivariable logistic regression model, hepatitis B surface antigen positivity, circulating recombinant form (CRF) 55_01B, CRF08_BC, CRF59_01B, and subtype B were demonstrated as associated risk factors for PDR. The overall prevalence of PDR in Guangzhou was moderate, with relatively severe NNRTI resistance. Therefore, it remains crucial to continue monitoring PDR among newly diagnosed HIV\u2010infected individuals.<\/jats:p>","DOI":"10.1002\/jmv.29937","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T01:20:19Z","timestamp":1727313619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pretreatment drug resistance among people living with HIV from 2018 to 2022 in Guangzhou, China"],"prefix":"10.1002","volume":"96","author":[{"given":"Shiyun","family":"Lv","sequence":"first","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Infectious Disease Center, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-4268","authenticated-orcid":false,"given":"Yun","family":"Lan","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozu","family":"He","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Infectious Disease Center, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou 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People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Guangdong Diagnosis and Treatment Quality Control Center of AIDS and Hepatitis C Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-2756","authenticated-orcid":false,"given":"Liya","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengle","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Infectious Disease Center, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Infectious Disease Center, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Infectious Disease Center, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5711-8681","authenticated-orcid":false,"given":"Linghua","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"},{"name":"Infectious Disease Center, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.902537"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","unstructured":"LiaoZYS LiQ et al. 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