{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:02:45Z","timestamp":1787731365363,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Borna disease virus 1 (BoDV\u20101) is a neurotropic RNA virus that has been linked to fatal BoDV\u20101 encephalitis (BVE) in humans. Ferroptosis represents a newly recognized kind of programmed cell death that marked by iron overload and lipid peroxidation. Various viral infections are closely related to ferroptosis. However, the link between BoDV\u20101 infection and ferroptosis, as well as its role in BVE pathogenesis, remains inadequately understood. Herein, we used primary rat cortical neurons, human microglial HMC3 cells, and Sprague\u2012Dawley rats as models. BoDV\u20101 infection induced ferroptosis, as ferroptosis characteristics were detected (iron overload, reactive oxygen species buildup, decreased antioxidant capacity, lipid peroxidation, and mitochondrial damage). Analysis via qRT\u2010PCR and Western blot demonstrated that BoDV\u20101\u2010induced ferroptosis was mediated through Nrf2\/HO\u20101\/SLC7a11\/GPX4 antioxidant pathway suppression. Nrf2 downregulation was due to BoDV\u20101 infection promoting Nrf2 ubiquitination and degradation. Following BoDV\u20101\u2010induced ferroptosis, the PTGS2\/PGE2 signaling pathway was activated, and various intracellular lipid peroxidation products and damage\u2010associated molecular patterns were released, contributing to BVE occurrence and progression. More importantly, inhibiting ferroptosis or the ubiquitin\u2012proteasome system effectively alleviated BVE. Collectively, these findings demonstrate the interaction between BoDV\u20101 infection and ferroptosis and reveal BoDV\u20101\u2010induced ferroptosis as an underlying pathogenic mechanism of BVE.<\/jats:p>","DOI":"10.1002\/jmv.29945","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T03:49:24Z","timestamp":1728272964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis"],"prefix":"10.1002","volume":"96","author":[{"given":"Qing","family":"Tan","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases The First Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing 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of Chongqing Medical University Chongqing China"},{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhou","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases The First Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishi","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases The First Affiliated Hospital of Chongqing Medical University Chongqing China"},{"name":"Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing 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