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Our aim was to investigate TDR to nucleoside reverse transcriptase inhibitors (NRTIs), non\u2010nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase inhibitors (INIs), as well as to new drugs: lenacapavir, fostemsavir. Predictive sensitivity was evaluated for maraviroc and broadly neutralizing antibodies (bNAbs) (zinlirvimab and teropavimab). Between 2020 and 2023, 85 people with HIV (PWH) were diagnosed with primary HIV\u20101 infection (PHI). Pol and env sequences were analyzed and TDR was characterized according to the French ANRS algorithm. The genotypic\u2010based prediction of bNAbs sensitivity was based on HIV env amino acid signatures I108, I201, F353 for teropavimab and N325, N332, H330 for zinlirvimab. TDR to NRTIs, NNRTIs, PIs and INIs was evidenced in 8.2%, 12.9%, 4.7%, and 5.9% strains, respectively. Ten viruses were CXCR4\/dual mix. All viruses were susceptible to lenacapavir (100%) and 52% harbored resistance to fostemsavir. The genotypic profile was associated with a predictive positive value (PPV)\u2009&gt;\u200983% of susceptibility to both teropavimab and zinlirvimab for 23 viruses (31%), while 22 (29%) had a PPV between 62% and 75%, suggesting reduced susceptibility to both bNAbs as soon as primary infection. The surveillance of TDR evidenced at the time of PHI is important with regard to new strategies for HIV patients with virological failure and global implementation of PrEP using NRTI, INI such as recently approved injectable cabotegravir, and future long\u2010acting drugs such as lenacapavir and bNAbs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.29948","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T03:35:45Z","timestamp":1728012945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Susceptibility to lenacapavir, fostemsavir and broadly neutralizing antibodies in French primary HIV\u20101 infected patients in 2020\u20132023"],"prefix":"10.1002","volume":"96","author":[{"given":"Marie\u2010Laure","family":"Chaix","sequence":"first","affiliation":[{"name":"Laboratoire de virologie, H\u00f4pital Saint\u2010Louis APHP Paris France"},{"name":"INSERM, U944 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-4381","authenticated-orcid":false,"given":"Sarah","family":"Maylin","sequence":"additional","affiliation":[{"name":"Laboratoire de virologie, H\u00f4pital Saint\u2010Louis APHP Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Michel","family":"Molina","sequence":"additional","affiliation":[{"name":"INSERM, U944 Universit\u00e9 Paris Cit\u00e9 Paris France"},{"name":"Department of Maladies Infectieuses, H\u00f4pital Saint\u2010Louis\u2010Lariboisi\u00e8re Assistance Publique H\u00f4pitaux de Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffroy","family":"Liegeon","sequence":"additional","affiliation":[{"name":"Department of Maladies Infectieuses, H\u00f4pital Saint\u2010Louis\u2010Lariboisi\u00e8re Assistance Publique H\u00f4pitaux de Paris Paris 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