{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:50Z","timestamp":1787237750555,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Epstein\u2013Barr virus (EBV) is responsible for a spectrum of human diseases and demonstrates a considerable prevalence among various populations. Advances in molecular epidemiological research have enhanced our comprehension of EBV\u2010related pathologies. In this study, our objective was to examine the epidemiological profile and clinical features of EBV infection in Chongqing, China. We enrolled patients suspected of EBV\u2010related diseases who were admitted to the First Affiliated Hospital of Chongqing Medical University between May 2013 and November 2022. Inclusion criteria were based on those who underwent EBV\u2010specific immunofluorescence or plasma EBV\u2010DNA testing. Among 13\u2009584 inpatients, the overall seropositivity rates for EBNA\u20101\u2010IgG, EBV\u2010VCA\u2010IgM, EBV\u2010EA\u2010IgG, EBV\u2010EA\u2010IgA, EBV\u2010VCA\u2010IgA, and EBV\u2010DNA were 91.89%, 7.22%, 18.00%, 16.19%, 30.78%, and 18.00%, respectively. The seropositivity rate for EBNA\u20101\u2010IgG steadily increased with age. The seropositivity rate for VCA\u2010IgM, an indicator of acute EBV infection, was highest in patients aged 11\u201320 years at 26.41%, decreasing to 2%\u20136% in older patients. Additionally, among 205 outpatients, the EBV\u2010DNA positivity rate was 14.15%. In 3670 individuals from health check\u2010up centers, the seropositivity rates for EBV\u2010EA\u2010IgA and EBV\u2010VCA\u2010IgA were 11.96% and 28.09%, respectively, and the EBV\u2010DNA positivity rate was 11.92%, all of which were lower than those in inpatients. Among the 762 EBV\u2010DNA positive inpatients, adults aged 31\u201340 years were the least affected, with a seropositivity rate of 12.00%, which increased with age. The most common diseases associated with primary EBV infection were infectious mononucleosis (IM) (35.49%), followed by EBV infection (14.15%) and pneumonia (7.19%). The most common diseases associated with EBV reactivation were pneumonia (16.80%), nasopharyngeal carcinoma (NPC) (11.02%), and autoimmune diseases (7.04%). Patients with hemophagocytic lymphohistiocytosis (HLH) had the highest viral load, significantly higher than those with NPC, pneumonia, and liver cirrhosis. This large\u2010scale retrospective study explores the epidemiological characteristics and disease spectrum of EBV infection across all age groups. The findings contribute to the improvement of diagnostic and management strategies for EBV infection.<\/jats:p>","DOI":"10.1002\/jmv.29960","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T01:53:46Z","timestamp":1728438826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Analysis of the epidemiology and clinical characteristics of Epstein\u2013Barr virus infection"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9414-3365","authenticated-orcid":false,"given":"Beining","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The First Affiliated Hospital of Chongqing Medical University Chongqing 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