{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:03:52Z","timestamp":1777943032512,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    High\u2010risk human papillomavirus (HPV) infections are responsible for cervical cancer. However, little is known about the differences between HPV types and risk categories regarding their genetic diversity and particularly APOBEC3\u2010induced mutations \u2013 which contribute to the innate immune response to HPV. Using a capture\u2010based next\u2010generation sequencing, 156 HPV whole genome sequences covering 43 HPV types were generated from paired cervical and anal swabs of 30 Togolese female sex workers (FSWs) sampled in 2017. Genetic diversity and APOBEC3\u2010induced mutations were assessed at the viral whole genome and gene levels. Thirty\u2010four pairwise sequence comparisons covering 24 HPV types in cervical and anal swabs revealed identical infections in the two anatomical sites. Differences in genetic diversity among HPV types was observed between patients. The E6 gene was significantly less conserved in low\u2010risk HPVs (lrHPVs) compared to high\u2010risk HPVs (hrHPVs) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009). APOBEC3\u2010induced mutations were found to be more common in lrHPVs than in hrHPVs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005), supported by our data and by using large HPV sequence collections from the GenBank database. Focusing on the most common lrHPVs 6 and 11 and hrHPVs 16 and 18, APOBEC3\u2010induced mutations were predominantly found in the E4 and E6 genes in lrHPVs, but were almost absent in these genes in hrHPVs. The variable APOBEC3 mutational signatures could contribute to the different oncogenic potentials between HPVs. Further studies are needed to conclusively determine whether APOBEC3 editing levels are associated to the carcinogenic potential of HPVs at the type and sublineage scales.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70002","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T03:08:28Z","timestamp":1728875308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Viral whole genome sequencing reveals high variations in APOBEC3 editing between HPV risk categories"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2196-6141","authenticated-orcid":false,"given":"Valentine Marie","family":"Ferr\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm IAME UMR 1137 Paris F\u201075018 France"},{"name":"Service de Virologie, AP\u2010HP, H\u00f4pital Bichat \u2013 Claude Bernard Paris F\u201075018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-5928","authenticated-orcid":false,"given":"Romain","family":"Copp\u00e9e","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm IAME UMR 1137 Paris F\u201075018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fifonsi A.","family":"Gbeasor\u2010Komlanvi","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sant\u00e9 Publique Universit\u00e9 de Lom\u00e9, Facult\u00e9 des Sciences de la Sant\u00e9 Lom\u00e9 Togo"},{"name":"Centre Africain de Recherche en Epid\u00e9miologie et en Sant\u00e9 Publique (CARESP) Lom\u00e9 Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Vacher","sequence":"additional","affiliation":[{"name":"Department of Genetics Institut Curie, PSL Research University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Bridier\u2010Nahmias","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm IAME UMR 1137 Paris F\u201075018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Bucau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pathologie AP\u2010HP, H\u00f4pital Bichat\u2010Claude Bernard Paris F\u201075018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounerou","family":"Salou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lom\u00e9, Centre de Biologie Mol\u00e9culaire et d'Immunologie Lom\u00e9 Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Lameiras","sequence":"additional","affiliation":[{"name":"Institut Curie, Genomics of Excellence (ICGex) Platform, PSL Research University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Couvelard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pathologie AP\u2010HP, H\u00f4pital Bichat\u2010Claude Bernard Paris F\u201075018 France"},{"name":"Universit\u00e9 de Paris, Centre of Research on Inflammation Paris INSERM U1149 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anoumou Claver","family":"Dagnra","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lom\u00e9, Centre de Biologie Mol\u00e9culaire et d'Immunologie Lom\u00e9 Togo"},{"name":"Programme national de lutte contre le sida et les infections sexuellement transmissibles Lom\u00e9 Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Bieche","sequence":"additional","affiliation":[{"name":"Department of Genetics Institut Curie, PSL Research University Paris France"},{"name":"INSERM U1016, Faculty of Pharmaceutical and Biological Sciences, Paris Cit\u00e9 University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Descamps","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Inserm IAME UMR 1137 Paris F\u201075018 France"},{"name":"Service de Virologie, AP\u2010HP, H\u00f4pital Bichat \u2013 Claude Bernard Paris F\u201075018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier K.","family":"Ekouevi","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Sant\u00e9 Publique Universit\u00e9 de Lom\u00e9, Facult\u00e9 des Sciences de la Sant\u00e9 Lom\u00e9 Togo"},{"name":"ISPED, Universit\u00e9 de Bordeaux &amp; 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