{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:03:48Z","timestamp":1777943028831,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Effective treatment to prevent hospitalization and death in people with COVID\u201019 exists, but people still need interventions that alleviate symptoms without drug interactions. Oral serum\u2010derived bovine immunoglobulins (SBI) may reduce symptoms and time\u2010to\u2010improvement in people with mild\u2010to\u2010moderate COVID\u201019. In this randomized, open\u2010label, single\u2010site study, participants with mild\u2010to\u2010moderate COVID\u201019 received SBI 5.0\u2009g bis in die (BID)\u2009+\u2009Standard of Care (SOC) or SOC alone (2:1) for 2 weeks. After 2 weeks, 78.8% of hospitalized participants on SBI\u2009+\u2009SOC improved by World Health Organization (WHO) scale of \u22653 compared to 61.1% on SOC alone (odds ratio: OR\u2009=\u20092.4;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0663), with older participants (&gt;57 years) showing more significant differences between the arms (OR\u2009=\u20096.1;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0109). Further, more participants on SBI\u2009+\u2009SOC reported absence of COVID\u201019 symptoms at Week 2 (74.2%) compared to SOC alone (43.6%; OR\u2009=\u20093.7;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0031), most notably the absence of dyspnea on exertion (OR\u2009=\u20094.4;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0047), with women exhibiting the most significant eradication of all symptoms (OR\u2009=\u20095.8;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0080). No difference in change of IL\u20106 between arms was observed. Overall, participants with mild\u2010to\u2010moderate COVID\u201019 on SBI\u2009+\u2009SOC had a shorter time\u2010to\u2010recovery than on SOC alone, with a significantly higher rate of complete resolution of symptoms. Dyspnea on exertion was the symptom most significantly impacted. For people with mild\u2010to\u2010moderate COVID\u201019, oral SBI could be a safe and effective intervention, devoid of drug interactions.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70005","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:44:46Z","timestamp":1728607486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum\u2010derived bovine immunoglobulin treatment in COVID\u201019 is associated with faster resolution of symptoms: A randomized pilot clinical trial"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-8670","authenticated-orcid":false,"given":"Netanya S.","family":"Utay","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases and Geographic Medicine University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-9161","authenticated-orcid":false,"given":"Roberto","family":"G\u00fcerri\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital del Mar. 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Pompeu Fabra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6247-6911","authenticated-orcid":false,"given":"Shahin","family":"Gharakhanian","sequence":"additional","affiliation":[{"name":"CIC: Cambridge Innovation Center Pharmaceutical Medicine &amp; Infectious Diseases, Shahin Gharakhanian MD Consulting LLC, One Broadway Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-7950","authenticated-orcid":false,"given":"David M.","family":"Asmuth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of California, Davis Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Contreras","sequence":"additional","affiliation":[{"name":"Proliant Health &amp; Biologicals Ankeny Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9319-6652","authenticated-orcid":false,"given":"Charlotte","family":"Kunkler","sequence":"additional","affiliation":[{"name":"Proliant Health &amp; Biologicals Ankeny Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Detzel","sequence":"additional","affiliation":[{"name":"Proliant Health &amp; Biologicals Ankeny Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4472-7503","authenticated-orcid":false,"given":"Christopher D.","family":"Warner","sequence":"additional","affiliation":[{"name":"Proliant Health &amp; Biologicals Ankeny Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2020-138234"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-5661"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.09.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25987"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00495-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21841"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.10.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21720"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.779064"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.054"},{"key":"e_1_2_10_14_1","volume-title":"COVID\u201019 Treatment Guidelines Panel. 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