{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:07:22Z","timestamp":1773029242946,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The hepatitis E virus (HEV) is an important causative agent of acute hepatitis (AH). Despite reports of human infection in Brazil, the investigation is not routinely conducted, even in cases of elevated liver enzymes. This study evaluated two groups: group 1\u2014patients with acute hepatitis A (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200944); group 2\u2014patients with nonA\u2010C AH (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200947). They were tested by enzyme immunoassay for anti\u2010HEV IgM\/IgG and real\u2010time PCR for HEV RNA detection. The positive sample for HEV RNA was submitted for sequencing. The seroprevalence of anti\u2010HEV IgM and IgG in group 1 was 4% (2\/44) and 14.5% (7\/44), respectively. Viral RNA was not detected in any sample. In group 2, the anti\u2010HEV IgM positivity was 4.3% (2\/47), and IgG 14.9% (7\/47). RNA was detectable in one case, which presented a viral load of 222.4 IU\/\u03bcL and positive anti\u2010HEV IgM\/IgG. In the phylogenetic analysis, the genotype identified was HEV\u20103f. These results indicate that HEV infection should be considered a possible diagnosis in cases of non\u2010A\u2013C AH. The patient identified with acute hepatitis E had recently traveled to the Northeast region of Brazil (Garanhuns city in Pernambuco state), where there are reports of high HEV seroprevalence among pigs. The close phylogenetic relationship observed between the sequence characterized in this study and strains isolated from pigs in nearby cities where the patient went suggested a possible zoonotic transmission in this region. This study highlights the importance of expanding studies and improving surveillance to understand better and manage HEV infections nationwide.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70024","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T05:28:36Z","timestamp":1731389316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Hepatitis Related to Hepatitis E Virus Genotype 3f Infection in Brazil"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-0702","authenticated-orcid":false,"given":"Leidiane B.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Gastroenterologia e Hepatologia Tropical, LIM\u201007 Instituto de Medicina Tropical, Faculdade de Medicina FMUSP, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-5336","authenticated-orcid":false,"given":"Luciana A.","family":"Reche","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gastroenterologia e Hepatologia Tropical, LIM\u201007 Instituto de Medicina Tropical, Faculdade de Medicina FMUSP, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-6156","authenticated-orcid":false,"given":"Ana C. de Seixas Santos","family":"Nastri","sequence":"additional","affiliation":[{"name":"Departamento de Doen\u00e7as Infecciosas e Parasit\u00e1rias Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-5060","authenticated-orcid":false,"given":"Fernanda de Mello","family":"Malta","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-5990","authenticated-orcid":false,"given":"Deyvid E.","family":"Amgarten","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-8960","authenticated-orcid":false,"given":"Luciana V. B.","family":"Casadio","sequence":"additional","affiliation":[{"name":"Departamento de Doen\u00e7as Infecciosas e Parasit\u00e1rias Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario P.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Instituto de Infectologia Em\u00edlio Ribas  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-0911","authenticated-orcid":false,"given":"Suzane K.","family":"Ono","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia Divis\u00e3o de Gastroenterologia e Hepatologia Clinica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-8108","authenticated-orcid":false,"given":"Maria C.","family":"Mendes\u2010Correa","sequence":"additional","affiliation":[{"name":"Departamento de Doen\u00e7as Infecciosas e Parasit\u00e1rias Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo  Sao Paulo Brazil"},{"name":"Laborat\u00f3rio de Virologia, LIM\u201052, Instituto de Medicina Tropical Faculdade de Medicina FMUSP, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-3105","authenticated-orcid":false,"given":"Flair J.","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia Divis\u00e3o de Gastroenterologia e Hepatologia Clinica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-0489","authenticated-orcid":false,"given":"Jo\u00e3o R. 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