{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:07:13Z","timestamp":1773029233248,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Studies have suggested an association between polymorphisms in class I genes of the major histocompatibility complex, specifically the human leukocyte antigen (HLA), and susceptibility to SARS\u2010CoV\u20102. To explore this, 135 individuals with positive serological tests for SARS\u2010CoV\u20102 were recruited. All the samples were collected before the advent of vaccines, avoiding immunization effects. Participants were divided into high and low neutralizing antibody titer groups, and polymorphisms in HLA\u2010A, HLA\u2010B, and HLA\u2010DRB1 genes were examined using PCR\u2010SSO. Allele prevalence in the study population was compared to the National Bone Marrow Volunteer Donors Register (REDOME) in S\u00e3o Paulo and between the high and low titer groups within the study population. Results indicated that the HLA\u2010B*15 polymorphism was more prevalent in the COVID\u201019 positive group compared to the control population (COVID\u201019\u2009=\u20090.1370; Control\u2009=\u20090.0875;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0067). The HLA\u2010B*18 polymorphism was less prevalent in the COVID\u201019 group (COVID\u201019\u2009=\u20090.0185; Control\u2009=\u20090.0534;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0064). Additionally, the HLA\u2010A*30 polymorphism was more prevalent in the high titer group within the (high\u2009=\u20090.10937; low\u2009=\u20090.02816;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0125). Other polymorphisms showed no significant differences. These findings align with international studies, suggesting these genes plays a role in COVID\u201019 pathophysiology, however, further research is required to fully understand their impact.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70028","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T04:37:30Z","timestamp":1731386250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HLA\u2010B*15 Is Associated With SARS\u2010CoV\u20102 Infection in a Brazilian Population"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-9570","authenticated-orcid":false,"given":"Jo\u00e3o V.","family":"Facco","sequence":"first","affiliation":[{"name":"Centro de Hematologia e Hemoterapia Universidade Estadual de Campinas \u2010 UNICAMP Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Addas\u2010Carvalho","sequence":"additional","affiliation":[{"name":"Centro de Hematologia e Hemoterapia Universidade Estadual de Campinas \u2010 UNICAMP Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana da Silva Santos","family":"Duarte","sequence":"additional","affiliation":[{"name":"Centro de Hematologia e Hemoterapia Universidade Estadual de Campinas \u2010 UNICAMP Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey B.","family":"Zangirolami","sequence":"additional","affiliation":[{"name":"Centro de Hematologia e Hemoterapia Universidade Estadual de Campinas \u2010 UNICAMP Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno D.","family":"Benites","sequence":"additional","affiliation":[{"name":"Centro de Hematologia e Hemoterapia Universidade Estadual de Campinas \u2010 UNICAMP Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-8068","authenticated-orcid":false,"given":"Sara T. O.","family":"Saad","sequence":"additional","affiliation":[{"name":"Centro de Hematologia e Hemoterapia Universidade Estadual de Campinas \u2010 UNICAMP Campinas Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201cCOVID\u201019 Cases | WHO COVID\u201019 Dashboard \u201dWHO accessed April 1 2024 https:\/\/data.who.int\/dashboards\/covid19\/cases?n=c."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn1755"},{"key":"e_1_2_11_4_1","unstructured":"\u201cCOVID\u201019 Vaccines | WHO COVID\u201019 Dashboard \u201d WHO accessed April 1 2024 https:\/\/data.who.int\/dashboards\/covid19\/vaccines?n=c."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00672-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-00663-w"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00846-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.9.948"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.416"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9710376"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13941"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2021.09.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06331-x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192114024"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.14387"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21155205"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2378"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2022.103513"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.605688"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.25005"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2023049920"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2020-206946"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:18:55Z","timestamp":1773026335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/jmv.70028"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70028","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70028"}}