{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:37:45Z","timestamp":1791380265903,"version":"4.3.3"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Severe fever with thrombocytopenia syndrome (SFTS), a tick\u2010borne infectious disease caused by the SFTS virus (SFTSV), is becoming a significant public health threat due to its high mortality rate. Knowledge of SFTSV in southeastern coastal China is limited. The whole genomes of 66 SFTSV strains collected from 2013 to 2023 in Hangzhou, a coastal city in China, were amplified and sequenced to elucidate the geography\u2010related genetic and pathogenic diversity. Hangzhou SFTSVs could be classified into five pure genotype groups (A, B\u20102, D, E, and F); genotype A was dominant, and genotype E was significantly associated with SFTS fatality. An unclassified sublineage of the L segment was proposed as a novel B\u20104 subgenotype. Seven types of genetic reassortants (abbreviated as B\u20103B\u20103B\u20101, CCA, B\u20102AB\u20102, B\u20102CB\u20102, DFD, B\u20104FF, and B\u20104B\u20102B\u20101 for the L, M, and S segments) were identified, including three novel forms. Six recombination events and ten amino acid substitutions were identified in the Hangzhou viruses. Collectively, our results demonstrated that all known SFTSV genotypes co\u2010circulated in Hangzhou, leading to a gradual increase in genetic diversity and the generation of novel reassortants. Increased surveillance is urgently needed in Hangzhou, a critical region for SFTSV genetic exchange.<\/jats:p>","DOI":"10.1002\/jmv.70029","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T04:38:08Z","timestamp":1731386288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multiple Genotypes and Reassortants of Severe Fever With Thrombocytopenia Syndrome Virus Co\u2010Circulating in Hangzhou in Southeastern China, 2013\u20132023"],"prefix":"10.1002","volume":"96","author":[{"given":"Yanping","family":"Wen","sequence":"first","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Ni","sequence":"additional","affiliation":[{"name":"Shangchen District Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hu","sequence":"additional","affiliation":[{"name":"Chun'an District Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Lin'an District Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yezhen","family":"Fang","sequence":"additional","affiliation":[{"name":"Shangchen District Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Huang","sequence":"additional","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2280-3989","authenticated-orcid":false,"given":"Shi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-1196","authenticated-orcid":false,"given":"Feifei","family":"Cao","sequence":"additional","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Xu","sequence":"additional","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6614-6086","authenticated-orcid":false,"given":"Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Lin'an District Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongnv","family":"Yu","sequence":"additional","affiliation":[{"name":"Chun'an District Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Huo","sequence":"additional","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4497-9305","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Hangzhou Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010095"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1911.130792"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit603"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2505.181463"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.190611"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit100"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv144"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06853-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24502"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.07.024"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-020-01391-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2015.1848"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.11.015"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2016.12.015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13061142"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129531"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-020-00289-0"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19563"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2081617"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0047"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08042-6"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.08.006"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2023.102277"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.07.007"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111127"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008186"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msy096"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mss075"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040088"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.38.89"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13010033"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188462"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03432-14"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vev003"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.152-160.1999"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2022.105238"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18063092"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.02.022"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1268440"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-020-04733-0"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2604.191011"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-023-02033-y"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-019-9174-8"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14020223"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020204"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70029","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:18:49Z","timestamp":1773026329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/jmv.70029"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70029","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70029"}}