{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:07:01Z","timestamp":1773029221874,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      We aimed to investigate the immune responses to homologous and heterologous COVID\u201019 booster vaccinations in renal transplant recipients (RTRs) and to identify factors affecting these responses. In this prospective multicenter observational study, we measured the antibody kinetics of 90 RTRs using the chemiluminescent microparticle immunoassay method. The mean age of participants was 45.2\u2009\u00b1\u200911.4 years, with 35.6% being female. On the 42nd day after the first vaccine dose, the median antibody level was 16.7 (IQR 2.5\u2212249.5) AU\/mL, and the seropositivity rate was 60% (\n                      <jats:italic>n\u2009<\/jats:italic>\n                      =\u200936). Mycophenolic acid (MFA) (OR: 0.087, 95% CI: 0.024\u22120.311) and ACE inhibitor use (OR: 0.203, 95% CI: 0.052\u22120.794) were identified as independent factors affecting seropositivity. Patients who received the Pfizer\/BioNTech booster had significantly higher antibody levels compared to those who received the CoronaVac\/Sinovac booster (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.021). Additionally, a significantly higher rate of COVID\u201019 positivity was observed among patients who received the CoronaVac\/Sinovac booster (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u20090.031). Heterologous COVID\u201019 booster vaccination is significantly more effective than homologous inactivated booster vaccination in enhancing immune responses and preventing new infections in RTRs. MFA and ACE inhibitor usage were independent factors affecting seropositivity. Additional COVID\u201019 vaccine doses are needed in this patient group.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmv.70030","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:43:40Z","timestamp":1730105020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heterologous Versus Homologous COVID\u201019 Boosters: Immune Response Outcomes in Renal Transplant Recipients"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-4112","authenticated-orcid":false,"given":"Yesim","family":"Yildiz","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-1831","authenticated-orcid":false,"given":"Emre","family":"Yasar","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erensu","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine Sebnem","family":"Karakan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Bilkent City Hospital Ankara Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-2439","authenticated-orcid":false,"given":"Ozant","family":"Helvaci","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-0092","authenticated-orcid":false,"given":"Hasan Selcuk","family":"Ozger","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Cemre Araz","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Nanotechnology, Neuroscience Interdisciplinary Program, UNAM\u2010National Nanotechnology Research Center Bilkent University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8737-9110","authenticated-orcid":false,"given":"Pinar Aysert","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asiye Ugras","family":"Dikmen","sequence":"additional","affiliation":[{"name":"Department of Public Health Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayhan","family":"Caglar","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Dizbay","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Gazi University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulver","family":"Derici","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galip","family":"Guz","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"\u201cConsiderations for Implementing and Adjusting Public Health and Social Measures in the Context of COVID\u201019 Interim Guidance \u201d WHO 2023 https:\/\/www.who.int\/publications\/i\/item\/who-2019-ncov-adjusting-ph-measures-2023.1."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.09.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2521-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.582201"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7774\/cevr.2023.12.1.13"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7869"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27714"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27714"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_10_11_1","unstructured":"Agencies of the Republic of Turkey Ministry of Health Turkey Medicine and Medical Device Institution. \u201cT\u00fcrkiye's Medicines and Medical Devices Agency has given emergency use approval to Coronavac \u201d accessed July 14 2023 https:\/\/www.titck.gov.tr\/haber\/kamuoyunun-dikkatine-13012021185623."},{"key":"e_1_2_10_12_1","unstructured":"Agencies of Turkish Radio and Television Corporation. \u201cThe Biontech vaccine has begun to be administered \u201d accessed September 2 2023 https:\/\/www.trthaber.com\/haber\/gundem\/biontech-asisi-uygulanmaya-baslandi-569556.html."},{"key":"e_1_2_10_13_1","unstructured":"\u201cCOVID\u201019 (SARS\u2010CoV\u20102 Infection) Laboratory Biosafety Guide \u201d T.R. Ministry of Health 2020 https:\/\/shgmtetkikdb.saglik.gov.tr\/TR-65016\/covid-19-sars-cov-2-enfeksiyonu-laboratuvar-biyoguvenlik-rehberi.html."},{"key":"e_1_2_10_14_1","unstructured":"\u201cInterim Laboratory Biosafety Guidelines for Handling and Processing Specimens Associated With Coronavirus Disease 2019 (COVID\u201019) \u201d CDC 2021 https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/lab\/lab-biosafety-guidelines.html."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.05.007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12091358"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2196\/35311"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00479-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00094-0"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab291"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16851"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001397"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-020-0455-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563220928361"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26695"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2021.100820"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101642"},{"key":"e_1_2_10_28_1","unstructured":"\u201cCOVID\u201019 Vaccines in the US \u201d CDC accessed August 2 2023 https:\/\/www.cdc.gov\/vaccines\/covid-19\/clinical-considerations\/interim-considerations-us.html."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7148e1"},{"key":"e_1_2_10_30_1","unstructured":"\u201cStay Up to Date With COVID\u201019 Vaccines \u201d CDC accessed June 12 2023 https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/stay-up-to-date.html."},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7142a4"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27714"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10101690"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.36519\/idcm.2023.216"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lansea.2022.100106"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103904"},{"key":"e_1_2_10_37_1","unstructured":"\u201cPeople Who Are Immunocompromised \u201d CDC accessed June 12 2023 https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/need-extra-precautions\/people-who-are-immunocompromised.html."},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31347-8"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:18:32Z","timestamp":1773026312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/jmv.70030"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70030","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2024-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70030"}}