{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:48:15Z","timestamp":1776725295939,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aims to explore the epidemiological characteristics of neuro\u2010specific antibodies (ns\u2010Ab) induced by different viral infections within the central nervous system (CNS). Additionally, it seeks to compare the autoimmune effects following several typical viral infections in CNS. We conduct a retrospective study to compare and analyze the prevalence trends of ns\u2010Ab in patients with different viral infections. Additionally, evaluate the intensity of CNS inflammatory responses postviral infection by correlating clinical characteristics and laboratory findings, and briefly demonstrate the immune effects in CNS following various viral infections. This study retrospectively collected data from 1037 patients hospitalized with suspected CNS infections. A total of 654 patients (63.1%) were included in the final analysis. A higher proportion of patients with pathogens present in their cerebrospinal fluid (CSF) (114 out of 332, 34.3%) tested positive for ns\u2010Ab compared to those without pathogens (70 out of 322, 21.7%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0004). Specifically, the screening rate for ns\u2010Ab in patients with CNS viral infections (83 out of 165, 50.3%) and the prevalence of ns\u2010Ab (27 out of 83, 32.5%) were significantly higher than in those with other pathogen infections (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016, respectively). Among these, human herpesvirus 7 (HHV7) patients had the highest detection rate of ns\u2010Ab during the disease course (11 out of 26, 42.3%), but exhibited infection characteristics distinctly different from those of herpes simplex virus 1 (HSV1). Viral infections significantly promote the development of autoimmune responses in CNS. The production of ns\u2010Ab and the subsequent autoimmune response vary across different viral infections. There is a strong statistical correlation between HHV7 and the presence of ns\u2010Ab, suggesting that HHV7 may serve as an early indicator of secondary autoimmune response following CNS infections.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70050","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T05:38:10Z","timestamp":1731562690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological Characteristics of Neuro\u2010Specific Antibodies Following Viral Infections"],"prefix":"10.1002","volume":"96","author":[{"given":"Yang","family":"Su","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jierui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songtao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine West China Hospital of Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Laboratory 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