{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:53:27Z","timestamp":1780606407414,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Natural killer (NK) cells play a pivotal role in the immune response against viral infections, including SARS\u2010CoV\u20102. However, our understanding of memory NK cell responses in the context of SARS\u2010CoV\u20102 remains limited. To address this, we investigated the memory\u2010like response of NK cells to SARS\u2010CoV\u20102 peptides, presented by autologous cells. Blood samples from 45 donors underwent analysis for SARS\u2010CoV\u20102 IgG antibodies, categorizing them into four groups based on the antibody kind and level. NK cells from SARS\u2010CoV\u20102\u2010experienced donors demonstrated enhanced degranulation and activation levels, IFN\u03b3 production and proliferative potential in response to SARS\u2010CoV\u20102 peptides. Investigation of highly proliferating NK cells demonstrated the formation of distinct clusters depending on the SARS\u2010CoV\u20102 peptide supplementation and the donor group. RNA sequencing revealed differential gene expression patterns, highlighting metabolism, protein transport, and immune response genes. Notably, KIR2DS4 expression correlated with enhanced IFN\u03b3 production, degranulation and proliferation levels, suggesting a role in SARS\u2010CoV\u20102 recognition. Collectively, these findings provide detailed insights into antigen\u2010specific NK cell responses to SARS\u2010CoV\u20102 peptides, indicating potential mechanisms underlying NK cell activation in antiviral immunity.<\/jats:p>","DOI":"10.1002\/jmv.70057","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T06:22:07Z","timestamp":1731565327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Antigen\u2010Specific Response of NK Cells to SARS\u2010CoV\u20102 Correlates With KIR2DS4 Expression"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-6508","authenticated-orcid":false,"given":"M. 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S.","family":"Drutskaya","sequence":"additional","affiliation":[{"name":"Division of Immunobiology and Biomedicine, Center of Genetics and Life Sciences Sirius University of Science and Technology Federal Territory Sirius Russia"},{"name":"Center for Precision Genome Editing and Genetic Technologies for Biomedicine Engelhardt Institute of Molecular Biology, Russian Academy of Sciences Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0430-790X","authenticated-orcid":false,"given":"D. 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