{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:51:56Z","timestamp":1783698716786,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Our objective was to evaluate the ramifications of the 2019 coronavirus disease (COVID\u201019) pandemic on the microbial profile and antimicrobial resistance patterns of bacteria isolated from cerebrospinal fluid (CSF) specimens of patients with bacterial meningitis. We conducted a retrospective analysis of laboratory results and clinical records about positive CSF cultures reported by the SPARSS network from 2017 to 2023. The study covered three distinct periods: January 2017 to December 2019 (before the COVID\u201019 pandemic), January 2020 to December 2022 (during the COVID\u201019 pandemic), and January 2023 to December 2023 (after the COVID\u201019 pandemic), with a total of 5793 CSF isolates collected. Notably, the proportion of male patients (61.3%) was higher than that of females. After COVID\u201019, we observed a notable shift in the seasonal peak of CSF pathogens, with a delay of approximately 3 months. Remarkable alterations were evident in both pediatric and adult CSF isolate profiles. In children, the predominant pathogens included coagulase\u2010negative\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    (CoNS),\n                    <jats:italic>Streptococcus pneumonia,<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    . Notably. After COVID\u201019, there was a significant decrease in the proportion of CoNS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0039) and a notable increase in\n                    <jats:italic>E. coli<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0067). In adults, the top three pathogens were CoNS,\n                    <jats:italic>Acinetobacter baumannii,<\/jats:italic>\n                    and\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    . After the pandemic, we observed a significant reduction in the prevalence of\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0059), while the proportions of\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>Enterobacter cloacae,<\/jats:italic>\n                    and\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    increased significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Additionally, among multidrug\u2010resistant bacteria, the detection rate of carbapenem\u2010resistant\n                    <jats:italic>E. coli<\/jats:italic>\n                    escalated (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0375). Antimicrobial susceptibility analysis indicated a declining trend in resistance rates for CoNS and\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    to certain antibiotics following the pandemic. Conversely, resistance to imipenem in\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    increased. In conclusion, the COVID\u201019 pandemic has significantly influenced the composition, antimicrobial resistance patterns, and epidemiological dynamics of CSF\u2010isolated bacteria in Shandong province. To effectively address these changes, ongoing and dynamic surveillance of pathogen trends and antimicrobial resistance rate is essential.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70063","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T05:48:58Z","timestamp":1731563338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of COVID\u201019 on the Prevalence and Drug Resistance of Bacteria Isolated From Bacterial Meningitis Cerebrospinal Fluid in Shandong Province: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"96","author":[{"given":"Chunyan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology Children's Hospital affiliated to Shandong University Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Children's Health and Disease Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Children's Hospital affiliated to Shandong University Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Children's Health and Disease Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Linyi People's Hospital Linyi Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoli","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yantai Yuhuangding Hospital Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-9518","authenticated-orcid":false,"given":"Shifu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Children's Hospital affiliated to Shandong University Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Children's Health and Disease Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(22)00155-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00022-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_97_22"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.20521"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1774"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-11111-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2811.220547"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11034-w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.3022-23"},{"key":"e_1_2_11_11_1","unstructured":"CLSI. \u201cPerformance Standards for Antimicrobial Susceptibility Testing \u201d33rd ed.CLSI supplement M100. 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