{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:32:22Z","timestamp":1791599542991,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>While the SARS\u2010CoV\u20102 vaccine offers 70%\u201395% protection effectiveness against Coronavirus disease 2019 (COVID\u201019), a portion of recipients do not produce adequate protective immune responses, particularly, neutralizing antibodies (nAbs). Previous studies of COVID\u201019 patients have identified several public antibody lineages, such as IGHV3\u201030, IGHV3\u201033, IGHV3\u201053, IGHV1\u201058, and IGHV1\u201024. However, it remains unclear how these public antibodies evolve during vaccination or whether there are any special antibody lineages correlated with SARS\u2010CoV\u20102 vaccination. In this study, through a combination of single B cell sequencing and next\u2010generation sequencing analysis, we systemically studied the dynamic changes of antibody lineages derived from different B cell germlines in their sequence, frequency, and neutralization ability in different vaccinees before and after receiving inactivated SARS\u2010CoV\u20102 vaccines. Our findings indicate that the frequency of antibodies derived from the IGHV4\u201034 lineage increased in most individuals after vaccination, and the higher frequency of the antibody usually resulted in stronger binding affinity. Additionally, the ratio of IGHV4\u201034 derived antibodies, when compared with other public antibodies, more strongly correlated with the neutralization activity of immune sera from vaccinees. Taken together, these results suggest that IGHV4\u201034 is a novel vaccine\u2010elicited public nAb lineage that plays a crucial role in immune response following inactivated COVID\u201019 vaccination.<\/jats:p>","DOI":"10.1002\/jmv.70073","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T03:59:10Z","timestamp":1732852750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Discovery of a Novel Public Antibody Lineage Correlated With Inactivated SARS\u2010CoV\u20102 Vaccine and the Resultant Neutralization Activity"],"prefix":"10.1002","volume":"96","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui 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