{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:57:37Z","timestamp":1780124257552,"version":"3.54.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Orthohantavirus hantanense<\/jats:italic>\n                    causes hemorrhagic fever with renal syndrome in Eurasia, posing a substantial public health threat. Although the Hantaan virus is the primary etiological agent in the Republic of Korea (ROK), evidence suggests the potential zoonotic transmission of the Amur virus (AMRV), closely related to the Soochong virus (SOOV), to humans in China and Russia. This study examined 31\n                    <jats:italic>Apodemus<\/jats:italic>\n                    spp. captured from six regions in Gangwon Province, ROK, between 2015 and 2018. Of these, 5\/31 (16.1%) tested positive for anti\u2010SOOV immunoglobulin G and SOOV RNA, with 3\/6 (50%) in Hongcheon\u2010gun and 2\/5 (40%) in Pyeongchang\u2010gun. Utilizing a multiplex polymerase chain reaction\u2010based next\u2010generation sequencing approach, we achieved complete genomic sequencing of SOOV from rodent lung tissues, with coverage rates of 90.3%\u221298.2% for the S segment, 92.3%\u221298.1% for the M segment, and 88.1%\u221293.0% for the L segment. Five novel whole\u2010genome sequences of SOOV were obtained from rodents in Hongcheon\u2010gun and Pyeongchang\u2010gun, representing the first documented SOOV in Pyeongchang\u2010gun. The evolutionary rate analysis of SOOV tripartite genomes demonstrated lower divergence in the S segment. Phylogenetic analysis revealed a well\u2010supported divergence of the SOOV and AMRV lineages across the ROK, China, and Russia, with incongruences suggesting differential segment evolution. Co\u2010divergence analysis indicated the inter\u2010species transmission of SOOV Aa18\u2010104 from\n                    <jats:italic>Apodemus agrarius<\/jats:italic>\n                    in Pyeongchang\u2010gun. The high zoonotic potential of all SOOV strains underscores the need for extensive monitoring and surveillance. This report provides crucial insights for the development of effective control strategies against hantaviral outbreaks in the ROK.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70077","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T06:01:56Z","timestamp":1732600916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiological Surveillance and Genomic Characterization of Soochong Virus From\n                    <i>Apodemus<\/i>\n                    Species Using Multiplex PCR\u2010Based Next\u2010Generation Sequencing, Republic of Korea"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2132-0674","authenticated-orcid":false,"given":"Kyungmin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Microbiology Korea University College of Medicine Seoul Republic of Korea"},{"name":"BK21 Graduate Program, Department 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