{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:41:11Z","timestamp":1791848471630,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The variola virus, the causative agent of smallpox, has claimed more human lives than all other infectious diseases combined. Consequently, any epidemiological event involving related viruses (orthopoxviruses) triggers significant concern, as was the case with the pandemic rise of monkeypox virus (MPXV), the causative agent of monkeypox in 2022\u22122023. Smallpox vaccines, based on vaccinia virus antigens, are expected to provide cross\u2010protection against MPXV. Studying the general seroprevalence of orthopoxviruses in populations worldwide is crucial for estimating susceptibility, risks, and the need for vaccination campaigns. In this study, we aimed to evaluate the seroprevalence of antibodies capable of recognizing MPXV in a Brazilian population and assess the potential for cross\u2010protection from previous smallpox vaccinations. We analyzed demographic data, vaccination records, and serum levels of anti\u2010MPXV IgG measured by enzyme\u2010linked immunosorbent assay (ELISA) in 319 volunteers from Barreiras, Bahia, Brazil. Our main findings show that the numbers of volunteers with serum samples recognizing MPXV in ELISA, as well as their serum levels of anti\u2010MPXV IgG, did not differ significantly according to gender or address type. However, both male and female elderly volunteers exhibited significantly higher concentrations of anti\u2010MPXV IgG than adults, youth, and children. These results suggest that the elderly may benefit from a cross\u2010reactive immune response due to previous smallpox vaccinations, whereas adults, youth, and children appear susceptible to MPXV. Further investigations involving other populations are necessary to assess the necessity of vaccinating potentially vulnerable groups.<\/jats:p>","DOI":"10.1002\/jmv.70083","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:39:32Z","timestamp":1732163972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Elderly Individuals Exhibit Elevated Levels of Anti\u2010Monkeypox Virus Antibodies Compared to Adults, Youth, and Children"],"prefix":"10.1002","volume":"96","author":[{"given":"Izabelle Caires Moreira","family":"dos Santos","sequence":"first","affiliation":[{"name":"Western Bahia Virology Institute, Center of Biological Sciences and Health Federal University of Western Bahia Barreiras Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Silva","family":"Souza","sequence":"additional","affiliation":[{"name":"Western Bahia Virology Institute, Center of Biological Sciences and Health Federal University of Western Bahia Barreiras Bahia Brazil"},{"name":"Department of Biological Sciences State University of Santa Cruz Ilh\u00e9us Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayanna Moreira Costa","family":"Foga\u00e7a","sequence":"additional","affiliation":[{"name":"Western Bahia Virology Institute, Center of Biological Sciences and Health Federal University of Western Bahia Barreiras Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth D\u00e1lety","family":"da Silva Brito","sequence":"additional","affiliation":[{"name":"Western Bahia Virology Institute, Center of Biological Sciences and Health Federal University of Western Bahia Barreiras Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"da Rocha Santos","sequence":"additional","affiliation":[{"name":"Western Bahia Virology Institute, Center of Biological Sciences and Health Federal University of Western Bahia Barreiras Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-2879","authenticated-orcid":false,"given":"Jaime Henrique","family":"Amorim","sequence":"additional","affiliation":[{"name":"Western Bahia Virology Institute, Center of Biological Sciences and Health Federal University of Western Bahia Barreiras Bahia Brazil"},{"name":"Department of Biological Sciences State University of Santa Cruz Ilh\u00e9us Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"\u201cPoxvirus Tropism \u201d Nature Reviews Microbiology accessed June 18 2024 https:\/\/www.nature.com\/articles\/nrmicro1099."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baaa062"},{"key":"e_1_2_12_4_1","unstructured":"WHO \u201cHistory of Smallpox Vaccination\u201d accessed June 20 2024 https:\/\/www.who.int\/news-room\/spotlight\/history-of-vaccination\/history-of-smallpox-vaccination."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00664-8"},{"key":"e_1_2_12_6_1","unstructured":"WHO \u201cMpox (monkeypox)\u201d accessed June 19 2024 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/monkeypox."},{"key":"e_1_2_12_7_1","unstructured":"Z.JezekandF.Fenner \u201cHuman Monkeypox\u201d accessed June 19 2024 https:\/\/karger.com\/books\/book\/1892\/Human-Monkeypox."},{"key":"e_1_2_12_8_1","unstructured":"\u201cHow It Spreads Mpox Poxvirus \u201d CDC March 1 2024 https:\/\/www.cdc.gov\/poxvirus\/mpox\/if-sick\/transmission.html."},{"key":"e_1_2_12_9_1","unstructured":"\u201cPrevention Mpox Poxvirus \u201d CDC March 1 2024 https:\/\/www.cdc.gov\/poxvirus\/mpox\/prevention\/index.html."},{"key":"e_1_2_12_10_1","unstructured":"\u201cVaccination Mpox Poxvirus \u201d CDC June 13 2024 https:\/\/www.cdc.gov\/poxvirus\/mpox\/interim-considerations\/overview.html."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2903.221231"},{"key":"e_1_2_12_12_1","unstructured":"\u201cInterim Clinical Considerations for Use of JYNNEOS Vaccine for Mpox Prevention in the United States Mpox Poxvirus \u201d CDC April 22 2024 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