{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:56:16Z","timestamp":1774544176289,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hematopoietic stem cell transplantation is a curative therapy for pediatric patients with malignancies and blood or immune system disorders. However, recipients are at risk of opportunistic infections, including cytomegalovirus infection, due to immunosuppression from conditioning regimens. This retrospective study analyzed 439 pediatric hematopoietic stem cell transplantation patients to identify risk factors for cytomegalovirus infection and assess the impact of conditioning regimens. Significant factors included graft source, graft versus host disease, and pre\u2010transplant clinically significant cytomegalovirus infection. Myeloablative conditioning regimens and the use of anti\u2010thymocyte globulin increased the risk of clinically significant cytomegalovirus infection. Additionally, the risk of cytomegalovirus infection in patients was found to be statistically significant in the myeloablative subgroup analyses who received anti\u2010thymocyte globulin alone and those who received both anti\u2010thymocyte globulin and total body irradiation. In our study, total body irradiation did not significantly affect the risk of clinically significant cytomegalovirus infection. This study covers a 10\u2010year period and a large pediatric patient population from a single center. Our findings highlight the importance of understanding risk factors for clinically significant cytomegalovirus infection to guide preventive strategies in pediatric HSCT recipients.<\/jats:p>","DOI":"10.1002\/jmv.70093","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:12:50Z","timestamp":1732684370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Understanding Risk Factors for Cytomegalovirus Infection in Pediatric Hematopoietic Stem Cell Transplantation: Insights From a 10\u2010Year Study Comparing Conditioning Regimens"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-4134","authenticated-orcid":false,"given":"Tu\u011fba","family":"Erat","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases Ankara Bilkent City Hospital Health Sciences University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-8731","authenticated-orcid":false,"given":"\u0130kbal Ok","family":"Bozkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology and Pediatric Bone Marrow Transplantation Unit Ankara Bilkent City Hospital Health Sciences University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8915-6922","authenticated-orcid":false,"given":"\u00d6zlem","family":"Mustafao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases Ankara Bilkent City Hospital Health Sciences University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4896-4143","authenticated-orcid":false,"given":"\u015eerife Mehtap","family":"Kanbur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology and Pediatric Bone Marrow Transplantation Unit Ankara Bilkent City Hospital Health Sciences University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0839-1301","authenticated-orcid":false,"given":"Belgin","family":"G\u00fclhan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases Ankara Bilkent City Hospital Health Sciences University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2538-2872","authenticated-orcid":false,"given":"Saliha","family":"Kan\u0131k\u2010Y\u00fcksek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases Ankara Bilkent City Hospital Health Sciences University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-2461","authenticated-orcid":false,"given":"Asl\u0131nur","family":"\u00d6zkaya\u2010Parlakay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases Ankara Bilkent City Hospital Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-0681","authenticated-orcid":false,"given":"Nam\u0131k Ya\u015far","family":"\u00d6zbek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology and Pediatric Bone Marrow Transplantation Unit Ankara Bilkent City Hospital Health Sciences University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"665","volume-title":"Feigin and Cherry's Textbook of Pediatric Infectious Diseases","author":"Dvorak C. 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