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To address the prevalence and trend of HPV co\u2010infections in Japan, HPV\u2010type\u2010specific data from Japanese women (<jats:italic>n<\/jats:italic>\u2009=\u20098128) aged &lt;\u200940 years and newly diagnosed with cervical abnormalities at 24 hospitals between 2012 and 2023 were analyzed. These included cervical intraepithelial neoplasia grade 1\/2 (CIN1\/2, <jats:italic>n<\/jats:italic>\u2009=\u20092745), CIN3\/adenocarcinoma in situ (AIS) (<jats:italic>n<\/jats:italic>\u2009=\u20093953), and invasive cervical cancer (ICC, <jats:italic>n<\/jats:italic>\u2009=\u20091430). For women enrolled in this study since 2019, information on sexual behaviors was collected via a self\u2010administered questionnaire. Time\u2010trend analyses by disease category showed significant declines in the prevalence of multiple HPV infections in CIN1\/2 (49.1%\u221238.3%, <jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.0004), CIN3\/AIS (44.7%\u201331.5%, <jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.0002), and ICC (26.7%\u201310.5%, <jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u20090.0001) during the last decade. When these data were analyzed separately for women aged 20\u201329 and 30\u201339 years, similar declining trends were observed in each disease category. Using data from 2111 women for whom information on sexual history was available, the number of sexual partners was strongly associated with increased multiple HPV infections (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In conclusion, the declining prevalence of HPV co\u2010infections in cervical cancer and its precursors may reflect a decrease in sexual activity among Japanese women of reproductive age.<\/jats:p>","DOI":"10.1002\/jmv.70096","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T08:58:59Z","timestamp":1733475539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Declining Prevalence of Human Papillomavirus Co\u2010Infections Among Young Japanese Women With Cervical Cancer and Its Precursors"],"prefix":"10.1002","volume":"96","author":[{"given":"Eri","family":"Yoshiizumi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamiko","family":"Onuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa 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