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However, data on systemic dissemination and diversification are relatively scarce and come from immunologically impaired patients. Here, the presence and variability of SARS\u2010CoV\u20102 were assessed among 71 tissue samples obtained from multiple organs including lung, intestine, heart, kidney, and liver from 15 autopsies with positive swabs and no records of immunocompromise. The virus was detected in most organs in the majority of autopsies. All organs presented intra\u2010host single nucleotide variants (iSNVs) with low, moderate, and high abundances. The iSNV abundances observed within different organs indicate that the virus can mutate at one host site and subsequently spread to other parts of the body. In agreement with previous data from respiratory samples, our lung samples presented no more than 10 iSNVs each. But interestingly, when analyzing different organs we were able to detect between 11 and 45 iSNVs per case. Our results indicate that SARS\u2010CoV\u20102 can replicate, and evolve in a compartmentalized manner, in different body sites, which agrees with the \u201cviral reservoir\u201d theory. We elaborate on how compartmentalized evolution in multiple organs may contribute to SARS\u2010CoV\u20102 evolving so rapidly despite the virus having a proofreading mechanism.<\/jats:p>","DOI":"10.1002\/jmv.70107","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T06:39:36Z","timestamp":1733812776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multi\u2010Organ Spread and Intra\u2010Host Diversity of SARS\u2010CoV\u20102 Support Viral Persistence, Adaptation, and a Mechanism That Increases Evolvability"],"prefix":"10.1002","volume":"96","author":[{"given":"Julieta M.","family":"Manrique","sequence":"first","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) Ciudad Aut\u00f3noma de Buenos Aires Argentina"},{"name":"Laboratorio de Virolog\u00eda y Gen\u00e9tica Molecular (LVGM), Facultad de Ciencias Naturales y Ciencias de la Salud Universidad Nacional de la Patagonia San Juan Bosco Trelew Chubut Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Maffia\u2010Bizzozero","sequence":"additional","affiliation":[{"name":"Morgue Judicial de la Naci\u00f3n Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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