{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:30:20Z","timestamp":1792017020729,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Emerging evidence underscores the pivotal role of long noncoding RNAs (lncRNAs) as crucial regulators within the HIV life cycle. However, the precise functions and detailed mechanisms by which lncRNAs operate in HIV\u20101 highly exposed but persistently seronegative (HESN) individuals remain currently unknown. Through RNA sequencing analysis of the HESN individual and the matched control, we identified potential lncRNAs. Then, we conducted validation experiments at the population level, while cellular models of HIV\u20101 infection were constructed for functional experimental investigations in vitro. Subcellular localization of the identified lncRNA was determined, followed by an exploration of the specific regulatory mechanism underlying HIV resistance through some experiments, such as RNA pull\u2010down, western blot and Hirt assays. LncRNA LINC02453 is highly expressed in HESN. Moreover, LINC02453 is identified as a novel lncRNA associated with heightened resistance to HIV\u20101. LINC02453 is predominantly localized in the nucleus and binds to SEC13, a component of the nuclear pore complex, leading to the inhibition of HIV\u20101 replication by regulating key processes such as late reverse transcription, nuclear import, and DNA integration. Our findings suggest that LINC02453 may serve as a prospective target for the development of innovative anti\u2010HIV therapeutics.<\/jats:p>","DOI":"10.1002\/jmv.70116","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T11:08:37Z","timestamp":1734692917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long Noncoding RNA LINC02453 Inhibits HIV\u20101 Replication by Binding With SEC13 to Regulate the Viral Productive Cycle"],"prefix":"10.1002","volume":"96","author":[{"given":"Xiu","family":"Chen","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Engineering Center for Organoids and Organ\u2010on\u2010Chips of Highly Pathogenic Microbial Infections &amp; Biosafety III Laboratory, Life Science Institute Guangxi Medical University Nanning 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