{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:30:02Z","timestamp":1765269002686,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Studies investigating the impact of donor cytomegalovirus (CMV) positivity on the prognosis of liver transplantation (LT) recipients with HCC are currently lacking. A total of 21\u2009759 eligible LT recipients were identified in the UNOS database between January 2002 and June 2023. The patients were divided into the donor CMV\u2010seronegative (<jats:italic>n<\/jats:italic>\u2009=\u20097575) and CMV\u2010seropositive (<jats:italic>n<\/jats:italic>\u2009=\u200914\u2009814) groups. Moreover, the subgroup analyses by recipient age and gender were conducted. All patients were also divided into 18\u201340 (<jats:italic>n<\/jats:italic>\u2009=\u2009271), 40\u201360 (<jats:italic>n<\/jats:italic>\u2009=\u20099538), and \u2265\u200960 (<jats:italic>n<\/jats:italic>\u2009=\u200911\u2009950) groups, male (<jats:italic>n<\/jats:italic>\u2009=\u200916\u2009954) and female (<jats:italic>n<\/jats:italic>\u2009=\u20094805) groups, respectively. Patients in the donor CMV\u2010seropositive group had shorter overall survival (OS) and disease\u2010free survival (DFS) compared to those in the donor CMV\u2010seronegative group (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Donor CMV seropositivity was proved to be a risk factor for OS and DFS (both <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Patients receiving CMV\u2010seropositive liver grafts had shorter OS and DFS in the 40\u201360 and \u2265\u200960 groups (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Patients receiving CMV\u2010seropositive liver grafts had shorted OS and DFS only in the male group (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The receipt of donor CMV\u2010seropositive liver grafts is associated with shorter survival and a higher risk of HCC recurrence in LT recipients with HCC. These adverse effects are influenced by recipient age and gender.<\/jats:p>","DOI":"10.1002\/jmv.70150","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T12:18:42Z","timestamp":1736165922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Donor CMV\u2010Seropostive Grafts on Prognosis of Liver Transplantation for Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"97","author":[{"given":"Ze","family":"Xiang","sequence":"first","affiliation":[{"name":"Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yisu","family":"Song","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarui","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine 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